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首页> 外文期刊>The British journal of psychiatry : >Early-life adversity and orbitofrontal and cerebellar volumes in adults with obsessive–compulsive disorder: voxel-based morphometry study
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Early-life adversity and orbitofrontal and cerebellar volumes in adults with obsessive–compulsive disorder: voxel-based morphometry study

机译：强迫症成年人的早期生活逆境以及眶额和小脑体积：基于体素的形态计量学研究

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Background Early-life adversity is a risk for obsessivea€“compulsive disorder (OCD), but the impact at the neural level is less clear. Aims To investigate the association between brain volumes and early-life adversity in individuals with a diagnosis of OCD only. Method The Childhood Trauma Questionnaire (CTQ-28) was used to assess early-life adversity in 21 participants with OCD and 25 matched healthy controls. The relationship between global and regional brain volume and early-life adversity was measured using voxel-based morphometry (VBM). All data were corrected for multiple comparisons using family-wise error (FWE) at P 0.05. Results In the OCD group, correlations with total CTQ scores were positively associated with a larger right orbitofrontal cortex volume. Physical neglect was higher in the OCD group than in controls and was positively associated with larger right cerebellum volume in the OCD group only. Conclusions Larger brain volumes may reflect underlying developmental neuropathology in adults with OCD who also have experience of childhood trauma.
机译：背景技术早期生活中的逆境是强迫症（OCD）的风险，但在神经水平的影响尚不清楚。目的探讨仅诊断为OCD的个体的脑容量与早期逆境之间的关联。方法使用儿童创伤问卷（CTQ-28）评估了21名强迫症患者和25名相匹配的健康对照者的早期逆境。使用基于体素的形态计量学（VBM）测量了全球和区域脑容量与早期逆境之间的关系。在P <0.05时，使用家庭误差（FWE）对所有数据进行多次比较校正。结果在强迫症组中，与总CTQ得分的相关性与更大的右眶额叶皮质量呈正相关。强迫症组的身体疏忽高于对照组，并且仅与强迫症组的右小脑体积呈正相关。结论较大的脑容量可能反映了患有儿童期创伤经历的成人强迫症成年人的潜在发育神经病理学。

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