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首页> 外文期刊>The British journal of psychiatry : >Resting vagal activity in schizophrenia: meta-analysis of heart rate variability as a potential endophenotype
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Resting vagal activity in schizophrenia: meta-analysis of heart rate variability as a potential endophenotype

机译：精神分裂症中静息迷走神经活动：心率变异性作为潜在内表型的荟萃分析

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Background Cardiac vagal tone, indexed by heart rate variability (HRV), is a proxy for the functional integrity of feedback mechanisms integrating central and peripheral physiology. Aims To quantify differences in HRV in individuals with schizophrenia compared with healthy controls. Method Databases were systematically searched for studies eligible for inclusion. Random effect meta-analyses of standardised mean differences were calculated for vagal activity indicated by high-frequency HRV and the root mean square of successive Ra€“R interval differences (RMSSD). Results Thirty-four studies were included. Significant main effects were found for high-frequency HRV ( P = 0.0008; Hedges' g = a?’0.98, 95% CI a?’1.56 to a?’0.41, k = 29) and RMSSD ( P 0.0001; g = a?’0.91, 95% CI a?’1.19 to a?’0.62, k = 24), indicating lower vagal activity in individuals with schizophrenia than in healthy controls. Considerable heterogeneity was evident but effects were robust in subsequent sensitivity analyses. Conclusions Given the association between low HRV, threat processing, emotion regulation and executive functioning, reduced vagal tone may be an endophenotype for the development of psychotic symptoms.
机译：背景以心率变异性（HRV）为指标的迷走神经张力是整合中枢和外周生理的反馈机制功能完整性的代表。目的量化精神分裂症患者与健康对照者的HRV差异。方法系统地搜索数据库中符合纳入条件的研究。通过高频HRV和连续Ra€R间隔差的均方根（RMSSD）来计算迷走神经活动的标准化均值差的随机效应荟萃分析。结果共纳入34项研究。对于高频HRV（P = 0.0008; Hedges'g = a？'0.98，95％CI a？'1.56 to a？'0.41，k = 29）和RMSSD（P <0.0001; g = a≥0.91，95％CIa≥1.19至a≥0.62，k ＝ 24），表明精神分裂症患者的迷走神经活性低于健康对照者。明显的异质性是明显的，但是在随后的敏感性分析中效果很明显。结论鉴于低HRV，威胁处理，情绪调节和执行功能之间存在关联，迷走神经张力降低可能是精神病症状发展的内表型。

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