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首页> 外文期刊>The British journal of psychiatry : >Randomised controlled trial of early detection and cognitive therapy for preventing transition to psychosis in high-risk individuals
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Randomised controlled trial of early detection and cognitive therapy for preventing transition to psychosis in high-risk individuals

机译：预防和控制高危人群向精神病过渡的早期检测和认知治疗的随机对照试验

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Background There is interest in the possibility of indicated prevention of psychosis. There is a strong case for using psychological approaches to prevent transition to psychosis in high-risk patients. Aims To identify individuals at high risk of transition to psychosis, and psychological characteristics relevant to the development of psychosis in this group. Method The design of a randomised controlled trial of cognitive therapy for the prevention of psychosis in people at high risk (meeting operational criteria of brief or attenuated psychotic symptoms, or first-degree family history with functional decline) is outlined. The first patients recruited are compared with non-patient samples on cognitive and personality factors; an interim analysis of transition rate is reported. Results Cases ( n =31) were recruited mainly from primary care. Of the 23 high-risk patients monitored for 6-12 months, 5 (22%) made the transition to psychosis. The high-risk group scored significantly higher than non-patients on measures of schizotypy, metacognitive beliefs and dysfunctional self-schemas (sociotropy). Conclusions The findings validate the methods of identifying individuals at high risk of experiencing a psychotic episode. Compared with non-patient controls, the cases showed dysfunctional metacognitive beliefs and self-schemas.
机译：背景技术有兴趣对可能预防精神病的可能性进行研究。在高危患者中使用心理方法来预防向精神病的过渡是一个强有力的案例。目的确定该人群中高度可能患精神病的人以及与精神病发展相关的心理特征。方法概述了一项针对高危人群（符合短暂或轻度精神病症状的操作标准，或功能下降的一级家族史）的预防性精神病的认知疗法随机对照试验的设计。将招募的第一批患者与非患者样本进行认知和人格因素比较;报告了过渡率的中期分析。结果31例病例主要来自初级保健。在接受监测的6至12个月的23位高危患者中，有5位（22％）转变为精神病。高风险组在精神分裂症，元认知信念和机能障碍（社会嗜性）方面的得分显着高于非患者。结论这些发现证实了识别高风险患者的方法。与非患者对照组相比，这些病例表现出功能障碍的元认知信念和自我模式。

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