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Effectiveness of a brief cognitive—behavioural therapy intervention in the treatment of schizophrenia

机译：短暂的认知行为干预在精神分裂症治疗中的有效性

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Background Little evidence exists to indicate whether community psychiatric nurses can achieve the results reported by expert cognitivea€”behavioural therapists in patients with schizophrenia. Aims To assess the effectiveness and safety of a brief cognitivea€”behavioural therapy (CBT) intervention in a representative community sample of patients with schizophrenia in secondary care settings. Method A pragmatic randomised trial was performed involving 422 patients and carers to compare a brief CBT intervention against treatment as usual. Results Patients who received CBT ( n =257) improved in overall symptomatology ( P =0.015; number needed to treat [NNT]=13), insight ( P 0.001; NNT=10) and depression ( P =0.003; NNT=9) compared with the controlgroup ( n =165). Insight was clinically significantly improved (risk ratio=1.15, 95% CI 1.01-1.31). There was no increase in suicidal ideation. Conclusions Community psychiatric nurses can safely and effectively deliver a brief CBT intervention to patients with schizophrenia and their carers.
机译：背景技术几乎没有证据表明社区精神科护士是否可以达到精神分裂症患者的专业认知行为治疗师所报告的结果。目的在二级保健机构中，对精神分裂症患者的代表性社区样本进行简短的认知行为疗法（CBT）干预的有效性和安全性评估。方法对422名患者和护理人员进行了一项务实的随机试验，以比较短暂的CBT干预与通常的治疗。结果接受CBT的患者（n = 257）的总体症状有所改善（P = 0.015;治疗[NNT] = 13所需的人数），洞察力（P <0.001; NNT = 10）和抑郁症（P = 0.003; NNT = 9 ）与对照组（n = 165）进行比较。洞察力在临床上显着改善（风险比= 1.15，95％CI 1.01-1.31）。自杀意念没有增加。结论社区精神科护士可以安全有效地为精神分裂症患者及其护理人员提供简短的CBT干预。

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