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首页> 外文期刊>The British journal of psychiatry : >Depression and mortality in a high-risk population
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Depression and mortality in a high-risk population

机译：高危人群的抑郁和死亡率

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Background It is not clear whether the increased mortality associated with depression can be explained by the effects of potential confounding variables. Aims To measure the effect of depression on mortality after controlling for cognitive decline, cardiovascular risk factors and antidepressant use. Method A prospective cohort study derived from data from a multi-centre randomised controlled trial of moderate hypertension. A total of 2584 participants, aged 65-75 years at study entry, were followed up for 11 years. Results Depression on the SelfCAREa€”D scale was associated with mortality after controlling for gender. After controlling for cardiovascular risk factors, cognitive decline and antidepressant use, depression continued to have a modest effect (hazard ratio=1.43; 95% C11.03-1.98). Depression in males and in people aged under 70 years significantly increased the risk of death. Conclusions Depression was associated with mortality only after controlling for gender. There was a modest but robust association between depression and mortality that was not explained by confounding by cardiovascular risk factors, cognitive decline or history of antidepressant use.
机译：背景尚不清楚是否可以通过潜在的混杂变量的影响来解释与抑郁症相关的死亡率增加。目的在控制认知能力下降，心血管危险因素和抗抑郁药使用后，测量抑郁对死亡率的影响。方法前瞻性队列研究来自中度高血压多中心随机对照试验的数据。共有2584名参与者（年龄为65-75岁）参加了研究，随访时间为11年。结果在控制性别之后，SelfCAREaD量表的抑郁与死亡率相关。在控制了心血管危险因素，认知能力下降和使用抗抑郁药后，抑郁症继续产生中度的影响（危险比= 1.43; 95％C11.03-1.98）。男性和70岁以下的人抑郁会大大增加死亡风险。结论抑郁仅在控制性别后才与死亡率相关。抑郁与死亡率之间存在适度但有力的关联，但心血管危险因素，认知能力下降或使用抗抑郁药的历史并不能解释这种关联。

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