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Signs of asphyxia at birth and risk of schizophrenia

机译：出生时窒息的迹象和精神分裂症的风险

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Background Previous research has found an association between obstetric complications and schizophrenia, but in many studies the sample size was limited, and no assessment of specific exposures was possible. Aims To assess the role of different complications, and in particular to distinguish between disordered foetal development and hypoxia at birth. Method From the Stockholm County In-Patient Register and community registers, we identified 524 cases of schizophrenia and 1043 controls, matched for age, gender, hospital and parish of birth. Data on obstetric complications were obtained from birth records. Results There was a strong association between signs of asphyxia at birth and schizophrenia (OR 4.4; 95% C11.9-10.3) after adjustment for other obstetric complications, maternal history of psychotic illness and social class. Conclusions Signs of asphyxia at birth are associated with an increased risk of schizophrenia in adults.
机译：背景技术先前的研究发现产科并发症与精神分裂症之间存在关联，但在许多研究中，样本量有限，无法评估具体的暴露水平。目的评估不同并发症的作用，尤其是区分胎儿发育异常和出生时的缺氧。方法从斯德哥尔摩县住院患者登记簿和社区登记簿中，我们确定了524例精神分裂症病例和1043例对照者，并与年龄，性别，住院和教区相匹配。产科并发症的数据来自出生记录。结果调整其他产科并发症，产妇精神病史和社会阶层后，出生时窒息的迹象与精神分裂症之间存在密切关联（OR 4.4; 95％C11.9-10.3）。结论出生时窒息的迹象与成人精神分裂症的风险增加有关。

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