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Obstetric complications and risk of schizophrenia

机译：产科并发症和精神分裂症的风险

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Background Obstetric complications have been studied frequently as possible risk factors for schizophrenia. Aims To test the hypotheses that individual obstetric complications are most strongly associated with an increased risk of schizophrenia in males, in patients with an early age at first diagnosis and in subjects with a maternal history of psychosis. Method Cases of schizophrenia diagnosed between January 1971 and June 1994 were identified in the Stockholm County In-Patient Register. Controls were matched on age, gender, hospital of birth and parish of birth. Obstetric data were recorded blind to casea€”control status for 524 cases and 1043 controls. Results This study did not find any large or consistent effect of gender, age at diagnosis or maternal history of psychosis on the risk of schizophrenia associated with individual complications. Conclusions Future studies should examine these effects using a much larger sample that includes patients with schizophrenia and control subjects whose genetic risk of schizophrenia has been assessed accurately.
机译：背景产科并发症已作为精神分裂症的可能危险因素而被频繁研究。目的为了检验以下假设：男性，初诊时年龄较早的患者以及有精神病史的受试者中，个别产科并发症与精神分裂症的风险增加最密切相关。方法在斯德哥尔摩县病人登记册中鉴定出1971年1月至1994年6月间诊断为精神分裂症的病例。对照在年龄，性别，出生医院和教区中匹配。 524例病例和1043例对照的盲目病例记录了产科数据。结果本研究未发现性别，诊断时的年龄或精神病的母性史对与个体并发症相关的精神分裂症风险有任何大的或一致的影响。结论未来的研究应使用更大的样本来检查这些影响，其中包括精神分裂症患者和控制对象，他们的精神分裂症遗传风险已得到准确评估。

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