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Tryptophan depletion and its implications for psychiatry

机译：色氨酸耗竭及其对精神病学的影响

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Background Over the past 10 years the technique of tryptophan depletion has been used increasingly as a tool for studying brain serotonergic systems. Aims To review the technique of tryptophan depletion and its current status as a tool for investigating psychiatric disorders. Method Systematic review of preclinical and clinical studies. Results Tryptophan depletion produces a marked reduction in plasma tryptophan and consequently brain serotonin (5-HT) synthesis and release. In healthy volunteers the effects of tryptophan depletion are influenced by the characteristics of the subjects and include some mood lowering, some memory impairment and an increase in aggression. In patients with depression tryptophan depletion tends to result in no worsening of depression in untreated subjects but a relapse in those who have responded to antidepressants (particularly serotonergic agents). In panic disorder the results are similar. Conclusions The findings that tryptophan depletion produces a relapse of symptoms in patients with depression and panic disorder who have responded to treatment with antidepressants suggests that enhanced 5-HT function is important in maintaining response in these conditions.
机译：背景技术在过去的十年中，色氨酸耗竭技术已越来越多地用作研究脑血清素能系统的工具。目的回顾色氨酸耗竭技术及其作为研究精神疾病的工具的当前状态。方法临床前和临床研究的系统评价。结果色氨酸耗竭可显着降低血浆色氨酸，从而降低脑5-羟色胺（5-HT）的合成和释放。在健康志愿者中，色氨酸耗竭的影响受受试者特征的影响，包括情绪降低，记忆力减退和攻击性增加。在患有抑郁症的患者中，色氨酸耗竭往往不会导致未经治疗的患者抑郁症的恶化，但是对抗抑郁药（尤其是血清素能药物）产生反应的患者复发。在恐慌症中，结果相似。结论对抗抑郁药治疗有反应的抑郁症和恐慌症患者，色氨酸耗竭会导致症状复发，这一发现表明，增强的5-HT功能对于在这些情况下维持反应至关重要。

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