• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American journal of pathology. >Identification of a Human Papillomavirus-Associated Oncogenic miRNA Panel in Human Oropharyngeal Squamous Cell Carcinoma Validated by Bioinformatics Analysis of The Cancer Genome Atlas
【24h】

Identification of a Human Papillomavirus-Associated Oncogenic miRNA Panel in Human Oropharyngeal Squamous Cell Carcinoma Validated by Bioinformatics Analysis of The Cancer Genome Atlas

机译：通过癌症基因组图谱的生物信息学分析验证了人类口咽鳞状细胞癌中与人乳头瘤病毒相关的致癌miRNA面板的鉴定

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

High-risk human papillomavirus (HPV) is a causative agent for an increasing subset of oropharyngeal squamous cell carcinomas (OPSCCs), and current evidence supports these tumors as having identifiable risk factors and improved response to therapy. However, the biochemical and molecular alterations underlying the pathobiology of HPV-associated OPSCC (designated HPV^+ OPSCC) remain unclear. Herein, we profile miRNA expression patterns in HPV^+ OPSCC to provide a more detailed understanding of pathologic molecular events and to identify biomarkers that may have applicability for early diagnosis, improved staging, and prognostic stratification. Differentially expressed miRNAs were identified in RNA isolated from an initial clinical cohort of HPV^+^/^- OPSCC tumors by quantitative PCR-based miRNA profiling. This oncogenic miRNA panel was validated using miRNA sequencing and clinical data from The Cancer Genome Atlas and miRNA in situ hybridization. The HPV-associated oncogenic miRNA panel has potential utility in diagnosis and disease stratification and in mechanistic elucidation of molecular factors that contribute to OPSCC development, progression, and differential response to therapy.
机译：高危型人乳头瘤病毒（HPV）是导致口咽鳞状细胞癌（OPSCC）增多的原因，目前的证据支持这些肿瘤具有可识别的危险因素并改善了对治疗的反应。然而，与HPV相关的OPSCC（称为HPV + OPSCC）的病理生物学基础的生化和分子改变仍不清楚。本文中，我们对HPV ^ + OPSCC中的miRNA表达模式进行了分析，以提供对病理分子事件的更详细了解，并鉴定出可能适用于早期诊断，改善分期和预后分层的生物标志物。通过基于PCR的miRNA定量分析，从HPV ^ + ^ / ^-OPSCC肿瘤的初始临床队列中分离的RNA中鉴定出差异表达的miRNA。使用癌症基因组图谱和miRNA原位杂交的miRNA测序和临床数据验证了该致癌miRNA面板。 HPV相关的致癌miRNA研究小组在诊断和疾病分层以及分子阐明有助于OPSCC发育，进展和对治疗的不同反应的分子机制方面具有潜在用途。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号