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首页> 外文期刊>The British journal of psychiatry : >Changes in regional cerebral blood flow due to cognitive activation among patients with schizophrenia
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Changes in regional cerebral blood flow due to cognitive activation among patients with schizophrenia

机译：精神分裂症患者认知活动引起的局部脑血流变化

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Background The regional cerebral blood flow (rCBF) response to the Wisconsin Card Sort Test (WCST) has been used to assess the functional integrity of the prefrontal cortex in patients with schizophrenia. Aims In this study, patients were divided into two groups according to whether they had made few or many perseverative errors on a modified version of the WCST. A control group consisted of normal volunteers. The groups were then compared with respect to rCBF response to WCST activation. Method rCBF was measured during administration of a modified version of the WCST and during a card sorting control task, using single photon emission computerised tomography (SPECT). Results Performance of the modified WCST was associated with a widespread and substantial increase in rCBF, particularly in the frontal region. The poorly performing group of patients with schizophrenia showed only a modest increase in rCBF in the left anterior cingulate region. Conclusion Subjects with schizophrenia are able to respond to specific neuropsychological challenge with activation of the frontal regions.
机译：背景技术对威斯康星卡片分类测试（WCST）的局部脑血流量（rCBF）反应已用于评估精神分裂症患者前额叶皮层的功能完整性。目的在本研究中，根据患者在WCST修改版上是否犯了很少或很多持久性错误，将其分为两组。对照组由正常志愿者组成。然后将各组的rCBF对WCST激活的反应进行比较。使用单光子发射计算机断层扫描（SPECT）在管理WCST的改进版本期间以及在卡片分类控制任务期间测量了rCBF。结果改良的WCST的性能与rCBF的广泛且大量增加有关，特别是在额叶区域。表现较差的精神分裂症患者在左前扣带回区的rCBF仅适度增加。结论精神分裂症患者能够通过激活额叶区域来应对特定的神经心理挑战。

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