...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British journal of psychiatry : >Schizophrenia with good and poor outcome. I: Early clinical features, response to neuroleptics and signs of organic dysfunction.
【24h】

Schizophrenia with good and poor outcome. I: Early clinical features, response to neuroleptics and signs of organic dysfunction.

机译：精神分裂症预后良好和不良。 I：早期临床特征，对精神抑制药的反应和器质性机能障碍的迹象。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Seventy-seven patients with diagnosis of schizophrenia (62) or schizoaffective disorder (15) were studied 2-20 years since onset of illness, when in a stable condition. The investigation included clinical assessment, measurement of plasma concentrations of neuroleptics and prolactin, computed tomography brain scan, neuropsychological and neurological examination. Outcome of illness was classified according to the presence of chronic psychiatric symptoms and social impairment, and response to neuroleptics according to the effect of treatment in the most recent psychotic episode. Neither outcome nor response to neuroleptics was related to duration of illness. The groups with good and poor outcome differed in premorbid adjustment, age at onset and symptoms of the initial episode, but not in drug bio-availability or prolactin response. Large cerebral ventricles and cognitive impairment, but not neurological 'soft' signs, were associated with unfavourable outcome. The three measures of organicity were not inter-related. No clinical differences were found between chronic patients with and without signs of organic dysfunction. The findings suggest that schizophrenia with good and unfavourable outcome may be separate sub-types. However, the role of organic factors in the latter group remains unclear.
机译：自疾病发作2-20年后，在病情稳定的情况下，对77例诊断为精神分裂症（62例）或分裂情感障碍（15例）的患者进行了研究。调查包括临床评估，抗精神病药和催乳素的血浆浓度测量，计算机断层扫描脑扫描，神经心理学和神经学检查。根据慢性精神病症状和社会障碍的存在对疾病的结果进行分类，并根据最近一次精神病发作中的治疗效果对神经镇痛药做出反应。结果和对精神抑制药的反应均与病程无关。结果好与差的组在病前调整，发病年龄和初始发作症状方面有所不同，但药物生物利用度或催乳素反应无差异。较大的脑室和认知障碍，而不是神经系统的“软”体征与不良预后相关。有机性的三个衡量标准不是相互关联的。没有器质性功能障碍迹象的慢性患者之间没有发现临床差异。这些发现表明，结果良好和不利的精神分裂症可能是不同的亚型。然而，有机因子在后一组中的作用仍不清楚。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号