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Relationship between antidepressant sales and secular trends in suicide rates in the Nordic countries

机译:北欧国家抗抑郁药销售与自杀率长期趋势之间的关系

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Background The effect of recent increases in antidepressant prescribing on population suicide rates is uncertain. Aims To investigate the relationship between antidepressant sales and trends in suicide rates. Method Graphical and quantitative assessment of trends in suicide and antidepressant sales in Norway, Sweden, Denmark and Finland. Results Suicide rates declined in all four countries during the 1990s, whereas antidepressant sales increased by 3- to 4-fold. Decreasing suicide rates in Sweden and Denmark preceded the rise in antidepressant sales by over 10 years, although the reductions accelerated between 1988 and 1990. In Norway, a modest but short-lived decline in suicide rates began around the time of the increase in antidepressant sales. In Finland, decreases in male suicide rates and to a lesser extent in female suicide rates began around the time of increased antidepressant sales. In all four countries decreases in suicide rates appeared to precede the widespread use of SSRIs. Conclusions We found mixed evidence that increases in antidepressant sales have coincided with a reduction in the number of suicides in Nordic countries.
机译:背景技术最近增加的抗抑郁药处方对人群自杀率的影响尚不确定。目的研究抗抑郁药销售与自杀率趋势之间的关系。方法图形和定量评估挪威,瑞典,丹麦和芬兰的自杀和抗抑郁药销售趋势。结果1990年代,所有四个国家的自杀率均下降,而抗抑郁药的销量则增长了3至4倍。瑞典和丹麦的自杀率下降先于抗抑郁药销售增长了10多年,尽管下降速度在1988年至1990年之间加速了。在挪威,自杀率的适度但短暂的下降始于抗抑郁药销售的增长之时。 。在芬兰,抗抑郁药销量的增加开始导致男性自杀率下降,女性自杀率下降幅度较小。在所有四个国家中,自杀率的下降似乎是在广泛使用SSRI之前。结论我们发现混杂的证据表明,抗抑郁药的销售增加与北欧国家自杀人数的减少同时发生。

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