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首页> 外文期刊>The British journal of psychiatry : >Aripiprazole in the treatment of the psychosis prodrome
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Aripiprazole in the treatment of the psychosis prodrome

机译：阿立哌唑治疗精神病前体

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Background Research studies for the treatment of the putative prodromal phase of psychotic disorders have begun to appear. Aims To obtain preliminary evidence of the short-term efficacy and safety of aripiprazole treatment in people with the psychosis prodrome. Method Fifteen participants meeting prodrome criteria (mean age 17.1 years, s.d.=5.5) enrolled in an open-label, single-site trial with fixed-flexible dosing of aripiprazole (5a€“30 mg/day) for 8 weeks. Results In the mixed-effects repeated-measures analysis, improvement from baseline on the Scale of Prodromal Symptoms total score was statistically significant by the first week. No participant converted to psychosis and 13 completed treatment. Neuropsychological measures showed no consistent improvement; mean weight gain was 1.2 kg. Akathisia emerged in 8 participants, but the mean Barnes Akathisia Scale score fell to baseline levels by the final visit. Adverse events were otherwise minimal. Conclusions Aripiprazole shows a promising efficacy and safety profile for the psychosis prodrome. Placebo-controlled studies are indicated.
机译：背景技术用于治疗精神病的推定前驱期的研究已经开始出现。目的获得阿立哌唑治疗精神病患者的近期疗效和安全性的初步证据。方法十五名符合prodrome标准（平均年龄17.1岁，s.d。= 5.5）的参与者参加了一项开放性单点试验，采用固定剂量的阿立哌唑（5至30毫克/天）连续8周。结果在混合效应重复措施分析中，前一周症状总评分量表相对于基线的改善在统计学上显着。没有参与者转变为精神病，完成了13项治疗。神经心理学指标未见持续改善。平均体重增加为1.2公斤。 Akathisia出现在8位参与者中，但到最后一次访视时，Barnes Akathisia量表的平均得分降至基线水平。否则不良事件极少。结论阿立哌唑显示出对精神病性综合征有希望的疗效和安全性。显示了安慰剂对照研究。

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