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首页> 外文期刊>The British journal of psychiatry : >Issues concerning feedback about genetic testing and risk of depression
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Issues concerning feedback about genetic testing and risk of depression

机译：有关基因检测和抑郁风险的反馈问题

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Background Recent studies show that adverse life events have a significantly greater impact on depression onset for those with the s/s allele of the genotype for the 5-HT gene-linked promoter region. Research in genes related to risk of depression leads to the question of how this information is received by individuals. Aims To investigate factors related to the response to receiving onea€?s own serotonin transporter genotype results. Method Predictors of the impact of receiving individual genotype data were assessed in 128 participants in a study of genea€“environment interaction in depression onset. Results Two-thirds decided to learn their individual genotype results (receivers) and prior to disclosure this decision was associated with a perception of greater benefit from receipt of the information (P=0.001). Receivers completing the 2-week (n=76) and 3-month follow-up (n=78) generally reported feeling pleased with the information and having had a more positive experience than distress. However, distress was related to genotype, with those with the s/s allele being most affected. Conclusions There was high interest in, and satisfaction with, learning about onea€?s serotonin transporter genotype. Participants appeared to understand that the gene conferred susceptibility to depression rather than a direct causal effect.
机译：背景技术最近的研究表明，对于具有5-HT基因连锁启动子区域基因型s / s等位基因的人，不良生活事件对抑郁发作的影响更大。对与抑郁风险有关的基因的研究引发了一个问题，即个人如何接收该信息。目的调查与收到自己的血清素转运蛋白基因型结果的反应相关的因素。方法在抑郁症发作的家​​系与环境相互作用研究中，对128位参与者进行了评估，以评估接收个体基因型数据的影响。结果三分之二的人决定学习他们各自的基因型结果（接收者），并且在披露之前，这一决定与从信息接收中获得更大收益的感知有关（P = 0.001）。接受2周（n = 76）和3个月随访（n = 78）随访的接受者普遍表示对信息感到满意，并且比痛苦更积极。但是，困扰与基因型有关，那些受S / s等位基因影响最大的是基因型。结论对一个人血清素转运蛋白基因型的学习引起了极大的兴趣和满意。与会者似乎了解到该基因使人容易患抑郁症，而不是直接因果关系。

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