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首页> 外文期刊>The British journal of psychiatry : >Efficacy of antidepressants and benzodiazepines in minor depression: systematic review and meta-analysis
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Efficacy of antidepressants and benzodiazepines in minor depression: systematic review and meta-analysis

机译：抗抑郁药和苯二氮卓类药物在轻度抑郁症中的疗效：系统评价和荟萃分析

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Background Depression is a common condition that has been frequently treated with psychotropics. Aims To review systematically the evidence of efficacy and acceptability of antidepressant and benzodiazepine treatments for patients with minor depression. Method A systematic review and meta-analysis of double-blind randomised controlled trials comparing antidepressants or benzodiazepines v. placebo in adults with minor depression. Data were obtained from MEDLINE, CINAHL, EMBASE, PsycInfo, Cochrane Controlled Trials Register and pharmaceutical company websites. Risk of bias was assessed for the generation of the allocation sequence, allocation concealment, masking, incomplete outcome data, and sponsorship bias. Results Six studies met inclusion criteria. Three studies compared paroxetine with placebo; fluoxetine, amitriptyline and isocarboxazid were studied in one study each. No studies compared benzodiazepines with placebo. In terms of failures to respond to treatment (6 studies, 234 patients treated with antidepressants and 234 with placebo) no significant difference between antidepressants and placebo was found (relative risk (RR) 0.94, 95% CI 0.81a€“1.08). In terms of acceptability, data extracted from two studies (93 patients treated with antidepressants and 93 with placebo) showed no statistically significant difference between antidepressants and placebo (RR = 1.06, 95% CI 0.65a€“1.73). There was no statistically significant between-study heterogeneity for any of the reported analyses. Conclusions There is evidence showing there is unlikely to be a clinically important advantage for antidepressants over placebo in individuals with minor depression. For benzodiazepines, no evidence is available, and thus it is not possible to determine their potential therapeutic role in this condition.
机译：背景抑郁症是精神病患者经常治疗的常见疾病。目的系统评价抗抑郁药和苯二氮卓类药物对轻度抑郁症患者的疗效和可接受性的证据。方法对抗抑郁药或苯二氮卓类药物与安慰剂对患有轻度抑郁症的成年人进行比较的双盲随机对照试验的系统评价和荟萃分析。数据来自MEDLINE，CINAHL，EMBASE，PsycInfo，Cochrane对照试验注册和制药公司网站。对于分配顺序的生成，分配隐藏，掩盖，不完整的结果数据和赞助偏差，评估了偏差的风险。结果六项研究符合纳入标准。三项研究将帕罗西汀与安慰剂进行了比较。一项研究分别研究了氟西汀，阿米替林和异卡巴肼。没有研究将苯二氮卓类药物与安慰剂进行比较。在对治疗失败的反应方面（6项研究，234名抗抑郁药患者和234名安慰剂患者），抗抑郁药与安慰剂之间无显着差异（相对风险（RR）0.94，95％CI 0.81a“ 1.08”）。在可接受性方面，两项研究（93例抗抑郁药患者和93例安慰剂患者）提取的数据显示，抗抑郁药和安慰剂之间无统计学差异（RR = 1.06，95％CI 0.65a？1.73）。对于任何报告的分析，研究间的异质性均无统计学意义。结论有证据表明，对于轻度抑郁症患者，抗抑郁药较安慰剂在临床上不太可能具有重要的优势。对于苯并二氮杂，没有可用的证据，因此不可能确定其在这种情况下的潜在治疗作用。

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