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首页> 外文期刊>The British journal of psychiatry : >Insight, grey matter and cognitive function in first-onset psychosis
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Insight, grey matter and cognitive function in first-onset psychosis

机译：初发精神病的洞察力，灰质和认知功能

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Background Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures. Aims Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis. Method Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight. Results The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus. Conclusions The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.
机译：背景几项研究表明，神经心理学和结构性脑缺陷与不良洞察​​力有关。然而，很少有见识研究将神经认知和结构神经解剖学措施相结合。目的着眼于将精神病性症状重新标记为病理性的能力，我们研究了初发性精神病的见识，脑结构和神经认知。方法基于Voxel的磁共振成像数据来自82例精神病患者和91名对照者，并通过简短的神经心理测试电池进行了评估。洞察力是使用洞察力评估计划来衡量的。结果主要分析表明，一般的神经心理功能下降与不良的症状再标记能力有关。随后的精神病人群之间的分析发现，那些没有症状重新标记能力的人具有明显的整体和区域灰质缺陷，主要位于扣带回和右前突/前突。结论扣带回（作为中线皮层系统的一部分）以及右半球区域可能与首次发作的精神病的疾病和症状自我评估有关。

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