• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British journal of psychiatry : >An early improvement threshold to predict response and remission in first-episode schizophrenia
【24h】

An early improvement threshold to predict response and remission in first-episode schizophrenia

机译：早期改善阈值，以预测首发精神分裂症的反应和缓解

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Early improvement with treatment is thought to be important in patients with first-episode schizophrenia, yet a valid definition is still outstanding. Aims To develop a valid definition of early improvement and test its predictive validity regarding response and remission. Method We examined 188 in-patients with first-episode schizophrenia. Early improvement was defined as improvement in Positive and Negative Syndrome Scale (PANSS) total score at week 2, response as a 40% PANSS total score improvement at end-point, and remission according to consensus criteria. Results Reasonable predictive validity of early improvement was found for a 46% PANSS total score improvement at week 2 and a 50% improvement for remission (area under the curve: response 0.707, remission 0.692). Estimated confidence intervals ranged from 26 to 62% PANSS reduction for response and remission. Conclusions Patients with a first episode of schizophrenia should improve by at least 30% in PANSS total score at week 2 to achieve response and remission.
机译：背景技术早期治疗对首发精神分裂症患者很重要，但有效的定义仍然很突出。目的建立早期改善的有效定义，并测试其对缓解和缓解的预测有效性。方法我们检查了188例首发精神分裂症住院患者。早期改善定义为第2周时阳性和阴性综合征量表（PANSS）总评分的改善，终点时PANSS总评分改善40％，根据共识标准缓解。结果发现合理的早期改善的预测有效性在第2周时PANSS总得分改善了46％，缓解率改善了50％（曲线下的面积：响应0.707，缓解度0.692）。估计置信区间的响应和缓解范围从PANSS减少26％到62％。结论第一次精神分裂症患者应在第2周的PANSS总评分中至少提高30％，以达到缓解和缓解的目的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号