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The dimensions of schizophrenia phenomenology. Not one or two, at least three, perhaps four.

机译:精神分裂症现象学的维度。没有一两个,至少三个,也许四个。

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BACKGROUND This confirmatory investigation examined the underlying structure of schizophrenia phenomenology through examination of the fit of several prominent dimensional models to observed symptom data. METHOD Confirmatory factor analysis was conducted on a correlation matrix of schizophrenia signs and symptoms derived from case history ratings of 192 individuals with schizophrenia who were the subjects in the major twin studies of schizophrenia. RESULTS Schizophrenia phenomenology appears best described by four underlying factors, namely negative symptoms, premorbid social adjustment deficits, reality distortion, and disorganisation. Of interest, the premorbid deficit dimension was directly associated with negative symptoms and disorganisation, but was inversely associated with reality distortion. CONCLUSIONS These data clearly support the multidimensionality of schizophrenia phenomenology and provide objective support for a four-factor model over other models. This four-factor model may be useful in organising existing and future data concerning the genetic, neurobiological, neurological, and psychosocial features of schizophrenia.
机译:背景技术该验证性研究通过检查几个突出的维度模型对观察到的症状数据的拟合,检查了精神分裂症现象学的基本结构。方法对精神分裂症体征和症状的相关矩阵进行验证性因素分析,该矩阵来自192例精神分裂症患者的病历,这些患者是精神分裂症主要双胞胎研究的对象。结果精神分裂症的现象学最好用四个基本因素来描述,即负面症状,病态前的社会适应缺陷,现实歪曲和混乱。有趣的是,病前缺陷的维度直接与消极症状和混乱有关,但与现实扭曲成反比。结论这些数据清楚地支持了精神分裂症现象学的多维性,并为四因素模型提供了客观的支持。这种四因素模型可能有助于组织有关精神分裂症的遗传,神经生物学,神经学和社会心理特征的现有和未来数据。

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