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首页> 外文期刊>The British journal of psychiatry : >Smoking habits and plasma lipid peroxide and vitamin E levels in never-treated first-episode patients with schizophrenia
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Smoking habits and plasma lipid peroxide and vitamin E levels in never-treated first-episode patients with schizophrenia

机译：未经治疗的精神分裂症首发患者的吸烟习惯，血浆脂质过氧化物和维生素E水平

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Background Lipid peroxidation may be increased in schizophrenia, due to the illness, lifestyle or medication. Aims To determine plasma lipid peroxide levels and serum vitamin E and A levels in first-episode never-treated people with schizophrenia and in controls. Method Thirty in-patients with a first episode of schizophrenia or schizophreniform psychosis were recruited, as were controls matched for gender, age, smoking and dietary status. Blood samples were taken, smoking status was recorded and body mass index measured. Results There were no significant differences between patients and controls in plasma lipid peroxide levels. Seventythree per cent of the patients smoked. Patients who smoked had a higher mean lipid peroxide level than non-smokers. Seventy-seven per cent of patients and 70% of controls had a ratio of vitamin E to cholesterol of less than 5. Body mass index was lower in patients than in controls. Conclusions As a result of the high prevalence of smoking this group shows increased lipid peroxidation. Low serum ratios of vitamin E to cholesterol in both patients and controls suggest an unsatisfactory diet.
机译：背景由于疾病，生活方式或药物治疗，精神分裂症中的脂质过氧化作用可能会增加。目的确定从未接受过治疗的精神分裂症患者和对照组的血浆脂质过氧化物水平以及血清维生素E和A水平。方法招募了30例首发精神分裂症或精神分裂症样精神病的住院患者，并根据性别，年龄，吸烟和饮食状况匹配了对照组。采集血样，记录吸烟状况并测量体重指数。结果患者和对照组血浆脂质过氧化物水平无明显差异。 73％的患者吸烟。吸烟患者的平均脂质过氧化物水平高于非吸烟者。 77％的患者和70％的对照者的维生素E与胆固醇之比小于5。患者的体重指数低于对照者。结论由于吸烟率高，该人群脂质过氧化增加。病人和对照组的维生素E与胆固醇的血清比率低表明饮食不理想。

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