• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British journal of psychiatry : >Association between atypical antipsychotic agents and type 2 diabetes: review of prospective clinical data
【24h】

Association between atypical antipsychotic agents and type 2 diabetes: review of prospective clinical data

机译：非典型抗精神病药与2型糖尿病之间的关联：前瞻性临床数据回顾

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Most evidence suggesting an association between schizophrenia, antipsychotic medications and diabetes has been based on retrospective studies not controlled for important confounders. Aims To compare diabetogenic risk between antipsychotic medications; and to describe the limitations of current prospective data-sets. Method Systematic review of prospective clinical data. Results No difference in the incidence of glycaemic abnormalities between placebo cohorts and antipsychotic medication cohorts was identified. No significant difference between any of the antipsychotic medications studied in terms of their association with glycaemic abnormalities was identified. Treatment-related weight gain did not appear to increase the riskof developing diabetes. Conclusions Diabetogenic potential ascribed to atypical antipsychotic drugs, resulting from retrospective studies, may be incorrect. Cohort sizes andincomplete sampling must preclude any definitive conclusions. Long-term, large, comparative prospective trials are needed, along with agreement upon glucose measurement of choice.
机译：背景大多数证据表明精神分裂症，抗精神病药物和糖尿病之间存在关联，这是基于对重要混杂因素没有控制的回顾性研究。目的比较抗精神病药物之间的致糖尿病风险;并描述当前预期数据集的局限性。方法对预期临床数据进行系统回顾。结果安慰剂组和抗精神病药物组之间的血糖异常发生率没有差异。在研究的任何抗精神病药物与血糖异常之间的关系上均未发现显着差异。与治疗有关的体重增加似乎并未增加患糖尿病的风险。结论回顾性研究表明，归因于非典型抗精神病药的致糖尿病潜力可能是错误的。队列规模和不完全抽样必须排除任何明确的结论。需要长期的，大型的，比较性的前瞻性试验，以及对选择的葡萄糖测量的同意。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号