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首页> 外文期刊>The British journal of psychiatry : >Cognitive impairment in bipolar II disorder
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Cognitive impairment in bipolar II disorder

机译：双相情感障碍II的认知障碍

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Background Persistentimpairments in neurocognitive function have been described in bipolar disorder. Aims To compare the cognitive performance of patients with bipolar II disorder with that of patients with bipolar I disorder and a healthy control group. Method The study included 71 euthymic patients with bipolar disorder (38 bipolar I, 33 bipolar II), who were compared on clinical and neuropsychological variables (e.g. executive function, attention, verbal and visual memory) and contrasted with 35 healthy controls on cognitive performance. Results Compared with controls, both bipolar groups showed significant deficits in most cognitive tasks including working memory (DigitSpan Backwards, P =0.002) and attention (DigitSpan Forwards, P =0.005; Trail Making Test, P =0.001). Those with type II disorders had an intermediate level of performance between the bipolar I group and the control group in verbal memory ( P 0.005) and executive functions (Stroop interference task, P =0.020). Conclusions Cognitive impairment exists in both subtypes of bipolar disorder, although more so in the bipolar I group. The best predictors of poor psychosocial functioning in bipolar II disorder were subclinical depressive symptoms, early onset of illness and poor performance on a measure related to executive function.
机译：背景已经在双相情感障碍中描述了神经认知功能的持续性障碍。目的比较双相II型障碍患者与双相I型障碍患者和健康对照组的认知表现。方法该研究包括71名患有躁郁症的正常人，其中38名躁郁症I，33名躁郁症II患者在临床和神经心理学变量（例如执行功能，注意力，言语和视觉记忆）上进行了比较，并与35名健康对照的认知表现进行了对比。结果与对照组相比，两个双极组在大多数认知任务中均表现出明显的缺陷，包括工作记忆（DigitSpan向后，P = 0.002）和注意力（DigitSpan前移，P = 0.005;跟踪测试，P = 0.001）。 II型障碍患者的言语记忆（P <0.005）和执行功能（Stroop干扰任务，P = 0.020）在双相I组和对照组之间的表现水平处于中等水平。结论认知障碍存在于双相情感障碍的两种亚型中，尽管在双相情感障碍I组中更为常见。躁郁症II的社会心理功能不良的最佳预测指标是亚临床抑郁症状，疾病的早期发作和与执行功能相关的某种程度的不良表现。

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