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首页> 外文期刊>The British journal of psychiatry : >Antidepressant therapy and C-reactive protein levels
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Antidepressant therapy and C-reactive protein levels

机译：抗抑郁药治疗和C反应蛋白水平

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Background Major depression is associated with activation of the inflammatory response. Aims To examine C-reactive protein levels in depression and to determine the impact of selective serotonin reuptake inhibitor (SSRI) therapy. Method Atwo-part study. In study 1, which used a between-subjects design, C-reactive protein was measured in 32 patients (20 currently depressed, 12 euthymic) with a history of DSMa€“IV major depression, all of whom were treated with an SSRI, and in a healthy comparison group ( n =20). Study 2 employed a within-subject design: C-reactive protein was measured in 20 patients with major depression both before and after SSRI treatment. Results In study 1, C-reactive protein levels did not differ between the group with depressive disorder (either currently depressed or euthymic) treated with SSRIs and the healthy group.In study 2 the protein levels dropped significantly following treatment with antidepressant medication. Conclusions Following SSRI treatment for major depression there is a significant drop in C-reactive protein concentrations whether or not the depression resolves. These findings indicate that antidepress-ants induce an anti-inflammatory response independent of antidepressant action.
机译：背景严重抑郁症与炎症反应的激活有关。目的检查抑郁症中的C反应蛋白水平，并确定选择性5-羟色胺再摄取抑制剂（SSRI）治疗的影响。方法分两部分进行研究。在采用受试者间设计的研究1中，对32例具有DSMa？IV重度抑郁病史的患者（其中20例目前处于抑郁状态，12例正常情况下）进行了C反应蛋白测定，所有患者均接受SSRI治疗，并且在健康的对照组中（n = 20）。研究2采用受试者内部设计：在SSRI治疗之前和之后，对20名重度抑郁症患者进行了C反应蛋白测定。结果在研究1中，SSRIs治疗的抑郁症组（目前处于抑郁或正常状态）与健康组的C反应蛋白水平没有差异。在研究2中，抗抑郁药治疗后蛋白水平显着下降。结论SSRI治疗重度抑郁症后，无论抑郁症是否缓解，C反应蛋白浓度均显着下降。这些发现表明抗抑郁药诱导了独立于抗抑郁药作用的抗炎反应。

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