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首页> 外文期刊>Pneumonia. >Upper airway viruses and bacteria detection in clinical pneumonia in a population with high nasal colonisation do not relate to clinical signs
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Upper airway viruses and bacteria detection in clinical pneumonia in a population with high nasal colonisation do not relate to clinical signs

机译：鼻定居率高的人群在临床肺炎中的上呼吸道病毒和细菌检测与临床体征无关

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Indigenous Australian children have high (up to 90%) rates of nasopharyngeal microbial colonisation and of hospitalisation for pneumonia. In Indigenous children hospitalised with pneumonia in Central Australia, we describe the nasopharyngeal detection of viruses and bacteria and assessed whether their presence related to signs of pneumonia (tachypnoea and/or chest in-drawing) on hospital admission and during subsequent days. Nasopharyngeal swabs (NPS) and data were prospectively collected from 145 children (median age = 23.5 months, interquartile range [IQR] 8.7–50) hospitalised with pneumonia at Alice Springs Hospital, Australia, between April 2001 and July 2002. The cohort was enrolled in a randomised controlled study using zinc and/or vitamin A supplementation. NPS were taken within 24 hours of hospitalisation and kept frozen at-80°C until analysed in 2014. Polymerase chain reaction (PCR) was used to detect Moraxella catarrhalis, Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus, Chlamydophila pneumoniae, Mycoplasma pneumoniae , and 16 respiratory viruses. Uni- and multi-variate analyses were used to examine the relationships. One or more organisms were present in 137 (94.5%) NPS; 133 (91.7%) detected ≥ 1 bacterium, 34 (37.2%) for ≥ 1 virus and 50 (34.5%) were positive for both viruses and bacteria. C. pneumoniae (n = 3) and M. pneumoniae (n = 2) were rare. In multi-variate analyses, age 12 months (odds ratio [OR] 6.6 [95% confidence interval {CI} 1.7–25.4]) and fever (OR 4.1 [95% CI 1.7–10.4]) were associated with tachypnoea and chest in-drawing. However the presence of bacteria and/or virus type was not associated with tachypnoea and/or chest in-drawing on admission or during recovery. In children with high nasopharyngeal microbial colonisation rates, the utility of NPS in determining the diagnosis of clinical pneumonia or duration of tachypnoea or in-drawing is likely limited. Larger cohort and case-control studies are required to confirm our findings.
机译：澳大利亚土著儿童的鼻咽微生物定植和肺炎住院率很高（高达90％）。在澳大利亚中部地区因肺炎住院的土著儿童中，我们描述了鼻咽病毒和细菌的检测，并评估了他们的入院时和入院后是否与肺炎的征兆（呼吸困难和/或胸部抽气）有关。前瞻性收集了2001年4月至2002年7月在澳大利亚爱丽斯泉医院住院的肺炎住院的145例儿童（中位年龄= 23.5个月，四分位范围[IQR] 8.7–50）的鼻咽拭子（NPS）和数据。在一项使用锌和/或维生素A补充剂的随机对照研究中。 NPS需在住院的24小时内服用，并保持在80°C冷冻，直到2014年进行分析。聚合酶链反应（PCR）用于检测卡他莫拉菌，流感嗜血杆菌，肺炎链球菌，金黄色葡萄球菌，肺炎衣原体，肺炎支原体和16种呼吸道病毒。使用单变量和多变量分析来检查这些关系。 137（94.5％）NPS中存在一种或多种生物。检出≥1种细菌的细菌为133（91.7％），≥1种病毒的细菌为34（37.2％），病毒和细菌均为阳性50株（34.5％）。肺炎衣原体（n = 3）和肺炎支原体（n = 2）很少。在多变量分析中，年龄<12个月（优势比[OR] 6.6 [95％置信区间{CI} 1.7–25.4]）和发烧（OR 4.1 [95％CI 1.7-10.4]）与呼吸急促和胸部相关绘图中。但是，细菌和/或病毒类型的存在与入院时或康复期间的呼吸急促和/或抽水无关。在鼻咽微生物定植率高的儿童中，NPS在确定临床肺炎或呼吸急促或吸气持续时间的诊断中的效用可能受到限制。需要更大的队列研究和病例对照研究来证实我们的发现。

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