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首页> 外文期刊>The British journal of psychiatry : >Frontotemporal dementia presenting as schizophrenia-like psychosis in young people: clinicopathological series and review of cases
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Frontotemporal dementia presenting as schizophrenia-like psychosis in young people: clinicopathological series and review of cases

机译：额颞痴呆表现为年轻人的精神分裂症样精神病：临床病理系列和病例回顾

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Background Few studies have investigated the relationship between schizophrenia and frontotemporal dementia. Aims To investigate this relationship through a clinicopathological investigation of young-onset frontotemporal dementia and a review of the case literature. Method Cases of young-onset frontotemporal dementia were identified within the local brain bank. The clinical course and pathological findings were collated. For the literature review, cases of frontotemporal dementia identified through Medline were selected according to defined criteria. The demographic, clinical, pathological and genetic characteristics of cases presenting with a psychotic illness were identified. Results In the case series, 5 of 17 patients with frontotemporal dementia had presented with a psychotic illness (schizophrenia/schizoaffective disorder n=4, bipolar disorder n=1) an average of 5 years prior to the dementia diagnosis. Patients with schizophrenia exhibited changes consistent with TDP-43 and ubiquitin-positive frontotemporal dementia. In the cases review, a third of patients aged 30 years or under and a quarter of those aged 40 years or under had been diagnosed with psychosis at presentation. Conclusions Patients with young-onset frontotemporal dementia may be diagnosed with a psychotic illness years before the dementia diagnosis is made. These findings have implications for clinicians and for our further understanding of the neurobiology of psychotic illness.
机译：背景很少有研究调查精神分裂症和额颞痴呆之间的关系。目的通过对年轻发病的额颞叶痴呆的临床病理学调查和病例文献复习来调查这种关系。方法在当地脑库中发现年轻的额颞叶痴呆病例。临床过程和病理结果进行了整理。为了进行文献综述，根据定义的标准选择了通过Medline确定的额颞叶痴呆病例。确定了患有精神病的病例的人口统计学，临床，病理和遗传学特征。结果在病例系列中，17例额颞叶痴呆患者中有5名在痴呆诊断之前平均5年出现精神病（精神分裂症/精神分裂症n = 4，躁郁症n = 1）。精神分裂症患者表现出与TDP-43和泛素阳性额颞叶痴呆相一致的变化。在病例回顾中，年龄在30岁或以下的患者中有三分之一，在40岁或以下的患者中有四分之一在就诊时被诊断出患有精神病。结论初发额颞叶痴呆患者可在作出痴呆诊断前数年被诊断出患有精神病。这些发现对临床医生以及我们对精神病神经生物学的进一步理解具有重要意义。

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