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首页> 外文期刊>The British journal of psychiatry : >Combined treatment with cognitive–behavioural therapy in adolescent depression: meta-analysis
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Combined treatment with cognitive–behavioural therapy in adolescent depression: meta-analysis

机译：青少年抑郁症的联合治疗与认知行为治疗：荟萃分析

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Background The treatment of adolescent depression is controversial and studies of combined treatment (antidepressants and cognitivea€“behavioural therapy, CBT) have produced conflicting findings. Aims To address the question of whether CBT confers additional benefit to antidepressant treatment in adolescents with unipolar depression for depressive symptoms, suicidality, impairment and global improvement. Method Meta-analysis of randomised controlled trials (RCTs) of newer-generation antidepressants and CBT in adolescent depression. Results There was no evidence of a statistically significant benefit of combined treatment over antidepressants for depressive symptoms, suicidality and global improvement after acute treatment or at follow-up. There was a statistically significant advantage of combined treatment for impairment in the short-term (at 12 weeks) only. There was some evidence of heterogeneity between studies. Conclusions Adding CBT to antidepressants confers limited advantage for the treatment of an episode of depression in adolescents. The variation in sampling and methodology between studies, as well as the small number of trials, limits the generalisability of the findings and any conclusions that can be drawn. Future studies should examine predictors of response to treatment as well as clinical components that may affect outcome.
机译：背景技术青少年抑郁症的治疗尚存争议，联合治疗（抗抑郁药和认知行为疗法，CBT）的研究产生了矛盾的发现。目的旨在解决CBT是否可为单相抑郁症青少年的抑郁症状，自杀倾向，功能障碍和整体改善提供额外的抗抑郁治疗益处。方法对青少年抑郁症中新一代抗抑郁药和CBT的随机对照试验（RCT）进行荟萃分析。结果没有证据表明在急性治疗或随访后，联合治疗比抗抑郁药具有抑郁症状，自杀倾向和整体改善的统计学意义。仅在短期内（第12周），联合治疗对损伤具有统计学上的显着优势。有证据表明研究之间存在异质性。结论在抗抑郁药中添加CBT可以在治疗青少年抑郁症方面提供有限的优势。研究之间抽样和方法的差异以及少量的试验限制了研究结果和可得出的任何结论的普遍性。未来的研究应检查对治疗反应的预测因素以及可能影响预后的临床因素。

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