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Epileptic, organic and genetic vulnerabilities for timing of the development of interictal psychosis

机译：发作间期精神病发作时的癫痫，器质性和遗传性脆弱性

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Background Age at the first psychotic episode and an interval between the onset of epilepsy and that of psychosis reflect developmental processes of interictal psychosis. However, factors relating to these indices remain unknown. Aims To identify clinical variables that are associated with the timing of the development of interictal psychosis. Method In 285 adults with epilepsy with interictal psychosis, effects of epileptic (epilepsy type), organic (intellectual functioning) and genetic (family history of psychosis) variables on timing of the development of psychosis were examined. Results The mean interval between the onset of epilepsy and that of psychosis was 14.4 years. Some psychosis occurred within a few years of the first seizure. Generalised epilepsy, normal intellectual function and a positive family history of psychosis were associated with early onset of psychosis. Conclusions Early development of interictal psychosis in people with epilepsy may reflect other individual vulnerabilities to psychosis rather than epilepsy-related damage.
机译：第一次精神病发作的背景年龄以及癫痫发作与精神病发作之间的间隔时间反映了发作性精神病的发展过程。但是，与这些指数有关的因素仍然未知。目的确定与发作间期精神病发生时间有关的临床变量。方法对285例成人间质性精神病癫痫患者的癫痫（癫痫型），器质性（智力功能）和遗传性（精神病家族史）变量对精神病发作时间的影响进行研究。结果癫痫发作与精神病发作之间的平均间隔为14.4年。首次发作后的几年内出现了一些精神病。广泛性癫痫，正常的智力功能和阳性的精神病史与精神病的早期发作有关。结论癫痫患者发作间期精神病的早期发展可能反映了其他个体对精神病的脆弱性，而不是癫痫相关的损害。

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