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首页> 外文期刊>The British journal of psychiatry : >Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia
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Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia

机译：精神分裂症伴随听觉幻觉的区域脑活动的时程

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Background The pathophysiology of auditory verbal hallucinations remains poorly understood. Aims To characterise the time course of regional brain activity leading to auditory verbal hallucinations. Method During functional magnetic resonance imaging, 11 patients with schizophrenia or schizoaffective disorder signalled auditory verbal hallucination events by pressing a button. To control for effects of motor behaviour, regional activity associated with hallucination events was scaled against corresponding activity arising from random button-presses produced by 10 patients who did not experience hallucinations. Results Immediately prior to the hallucinations, motor-adjusted activity in the left inferior frontal gyrus was significantly greater than corresponding activity in the right inferior frontal gyrus. In contrast, motor-adjusted activity in a right posterior temporal region overshadowed corresponding activity in the left homologous temporal region. Robustly elevated motor-adjusted activity in the left temporal region associated with auditory verbal hallucinations was also detected, but only subsequent to hallucination events. At the earliest time shift studied, the correlation between left inferior frontal gyrus and right temporal activity was significantly higher for the hallucination group compared with non-hallucinating patients. Conclusions Findings suggest that heightened functional coupling between the left inferior frontal gyrus and right temporal regions leads to coactivation in these speech processing regions that is hallucinogenic. Delayed left temporal activation may reflect impaired corollary discharge contributing to source misattribution of resulting verbal images.
机译：背景技术听觉幻觉的病理生理学仍然知之甚少。目的表征导致听觉口头幻觉的区域性大脑活动的时程。方法在功能性磁共振成像中，11名精神分裂症或精神分裂症患者通过按下按钮来发出听觉言语幻觉事件的信号。为了控制运动行为的影响，将与幻觉事件相关的区域活动与由10名未经历幻觉的患者产生的随机按钮按压产生的相应活动进行对比。结果幻觉前，左下额回的运动调节活动明显大于右下额回的相应活动。相反，右后颞区的运动调节活动掩盖了左同源颞区的相应活动。还检测到与听觉言语幻觉相关的左侧颞区的运动调节活动明显增强，但仅在幻觉事件之后发生。在最早的时移研究中，幻觉组的左下额回与右颞活动之间的相关性显着高于非晕动的患者。结论研究结果表明，左下额回和右颞区之间增强的功能耦合导致了这些致幻觉的语音处理区域的共激活。延迟的左颞部活动可能反映出推论力减弱，从而导致了所得到的言语图像的来源不正确。

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