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首页> 外文期刊>The British journal of psychiatry : >Moderating role of the MAOA genotype in antisocial behaviour
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Moderating role of the MAOA genotype in antisocial behaviour

机译：MAOA基因型在反社会行为中的调节作用

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Background Recent studies have examined gene?—environment (G?—E) interactions involving the monoamine oxidase A ( MAOA ) gene in moderating the associations between exposure to adversity and antisocial behaviour. The present study examined a novel method for assessing interactions between a single gene and multiple risk factors related to environmental and personal adversity. Aims To test the hypothesis that the presence of the low-activity MAOA genotype was associated with an increased response to a series of risk factors. Method Participants were 399 males from the Christchurch Health and Development Study who had complete data on: (a) MAOA promoter region variable number tandem repeat genotype; (b) antisocial behaviour (criminal offending) to age 30 and convictions to age 21; and (c) maternal smoking during pregnancy, IQ, childhood maltreatment and school failure. Results Poisson regression models were fitted to three antisocial behaviour outcomes (property/violent offending ages 15a€“30; and convictions ages 17a€“21), using measures of exposure to adverse childhood circumstances. The analyses revealed consistent evidence of G x E interactions, such that those with the low-activity MAOA variant who were exposed to adversity in childhood were significantly more likely to report offending in late adolescence and early adulthood. Conclusions The present findings add to the evidence suggesting that there is a stable G x E interaction involving MAOA , a range of adverse environmental and personal factors, and antisocial behaviour across the life course. These analyses also demonstrate the utility of using multiple environmental/personal exposures to test G?—E interactions.
机译：背景技术最近的研究已经检查了涉及单胺氧化酶A（MAOA）基因的基因-环境（Gα-E）相互作用，以调节逆境暴露与反社会行为之间的关联。本研究检验了一种评估单个基因与与环境和个人逆境有关的多种危险因素之间相互作用的新颖方法。目的为了检验以下假设：低活性MAOA基因型的存在与对一系列危险因素的反应增加有关。方法参与者是来自克赖斯特彻奇健康与发展研究的399名男性，他们具有以下方面的完整数据：（a）MAOA启动子区域可变数目串联重复基因型; （b）30岁之前的反社会行为（犯罪行为）和21岁以下的定罪行为; （c）孕妇在​​怀孕，智商，儿童时期的虐待和学业失败期间吸烟。结果泊松回归模型适用于三个反社会行为的结果（财产/暴力犯罪年龄为15至30岁;定罪年龄为17至21岁），并采用了暴露于儿童期不利环境的措施。分析揭示了G x E相互作用的一致证据，因此那些在童年时期经历过逆境的低活性MAOA变异者显着更有可能在青春期晚期和成年早期报告有病。结论本发现为证据表明存在稳定的G x E相互作用，涉及MAOA，一系列不利的环境和个人因素以及整个生命过程中的反社会行为。这些分析还证明了使用多次环境/个人接触来测试G？-E相互作用的效用。

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