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首页> 外文期刊>The British journal of psychiatry : >White matter microstructure in schizophrenia: effects of disorder, duration and medication
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White matter microstructure in schizophrenia: effects of disorder, duration and medication

机译：精神分裂症的白质微观结构：疾病，病程和药物治疗的影响

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Background Diffusion tensor magnetic resonance imaging studies in schizophrenia to date have been largely inconsistent. This may reflect variation in methodology, and the use of small samples with differing illness duration and medication exposure. Aims To determine the extent and location of white matter microstructural changes in schizophrenia, using optimised diffusion tensor imaging in a large patient sample, and to consider the effects of illness duration and medication exposure. Method Scans from 76 patients with schizophrenia and 76 matched controls were used to compare fractional anisotropy, a measure of white matter microstructural integrity, between the groups. Results We found widespread clusters of reduced fractional anisotropy in patients, affecting most major white matter tracts. These reductions did not correlate with illness duration, and there was no difference between age-matched chronically and briefly medicated patients. Conclusions The finding of widespread fractional anisotropy reductions in our larger sample of patients with schizophrenia may explain some of the inconsistent findings of previous, smaller studies.
机译：迄今为止，精神分裂症的背景扩散张量磁共振成像研究在很大程度上是不一致的。这可能反映了方法上的差异，以及疾病持续时间和药物暴露程度不同的小样本的使用。目的为了确定精神分裂症中白质微结构变化的程度和位置，在大量患者样本中使用优化的扩散张量成像，并考虑疾病持续时间和药物暴露的影响。方法对76例精神分裂症患者和76例相匹配的对照进行扫描，比较两组之间的分数各向异性（衡量白质微结构完整性的指标）。结果我们发现患者中广泛的集群的分数各向异性降低，影响了大多数主要的白质道。这些减少与疾病持续时间无关，年龄相匹配的慢性和短暂用药患者之间也没有差异。结论在我们较大的精神分裂症患者样本中发现广泛的分数各向异性降低，这可能解释了以前较小的研究中一些不一致的发现。

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