Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD

Cleo L. Crunelle; Geert Dom; Jan Booij; Wim van den Brink

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Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD

机译：成人多动症中哌醋甲酯对多巴胺转运蛋白的占用和冲动

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Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.

机译：冲动性是多维结构，包括冲动性决策和冲动性动作，代表相对独立的神经回路。 ADHD用哌醋甲酯治疗，哌醋甲酯是一种与多巴胺转运蛋白结合的药物。这项针对24位ADHD成年男性患者的研究表明，哌醋甲酯中哌醋甲酯对多巴胺转运蛋白的占用与认知能力的改善相关，但与运动冲动无关。

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《The British journal of psychiatry :》 |2014年第6期|共页
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Cleo L. Crunelle; Geert Dom; Jan Booij; Wim van den Brink;
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1. Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD [J] . CrunelleC.L., VanDenBrinkW., DomG., The British journal of psychiatry : . 2014,第6期

机译：成人多动症中哌醋甲酯对多巴胺转运蛋白的占用和冲动
2. Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence [J] . CrunelleC.L., vandenBrinkW., VeltmanD.J., European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology . 2013,第12期

机译：哌醋甲酯对多巴胺转运蛋白的占有率低可能是可卡因依赖性ADHD患者治疗效果降低的可能原因
3. A PET study examining pharmacokinetics and dopamine transporter occupancy of two long-acting formulations of methylphenidate in adults [J] . SpencerThomas j., BonabAli A., DoughertyDarin D., International journal of molecular medicine . 2010,第2期

机译：一项PET研究，研究了两种长效哌醋甲酯制剂在成人中的药代动力学和多巴胺转运蛋白占用
4. Brain Activation during Simon Task in ADHD with and without Methylphenidate as Revealed by fMRI [C] . Yufeng Zang, Xuchu Weng, Zhen Jin, International conference on cognitive science;ICCS 2001 . 2001

机译：功能磁共振成像显示，在有或无哌醋甲酯的ADHD中，Simon Task期间的大脑激活
5. Sibling-based association study of dopamine transporter, serotonin transporter, and dopamine-4 receptor polymorphisms and disordered eating behavior in young adults. [D] . Sobik, Laura Elizabeth. 2007

机译：基于兄弟姐妹的多巴胺转运蛋白，血清素转运蛋白和多巴胺-4受体多态性与年轻人饮食行为紊乱的关联研究。
6. Blood levels and dopamine transporter occupancy of orally administered methylphenidate in juvenile rhesus monkeys measured by high resolution PET [O] . Kristin M. Wilcox, Yun Zhou, Dean F. Wong, -1

机译：高分辨率PET测定幼年恒河猴口服哌醋甲酯的血药浓度和多巴胺转运蛋白占用
7. Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD [O] . Crunelle, Cleo L., van den Brink, Wim, Dom, Geert, 2014

机译：成年ADHD中哌醋甲酯对多巴胺转运蛋白的占用和冲动

Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD

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