Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer

Dean A Fennell; Charles Swanton

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Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer

机译：解锁潘多拉魔盒：个性化非小细胞肺癌中的癌细胞死亡

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Evasion of apoptosis is a hallmark of tumorigenesis and a recognised cause of multidrug resistance. Over the last decade, insights into how apoptosis might be exploited in non-small cell lung cancer ( NSCLC ) and how cancer therapeutics might be used to engage apoptotic signalling in a personalised manner have changed markedly. We are now in the wake of a paradigm shift in stratified therapeutic approaches related to NSCLC . At the heart of this shift in thinking is the emerging knowledge that even the most drug-resistant cancers exhibit a functional death pathway and, critically, that this pathway can be efficiently engaged, leading to clinical benefit. This review will summarise current knowledge of mitochondrial apoptotic pathway dysfunction in NSCLC and how the next generation of targeted therapeutics might be used to exploit deficiencies in apoptotic signalling in a personalised manner to improve clinical outcome and predict therapeutic benefit.

机译：规避细胞凋亡是肿瘤发生的标志，也是公认的多药耐药性原因。在过去的十年中，关于如何在非小细胞肺癌（NSCLC）中利用凋亡以及如何利用癌症治疗剂以个性化方式参与凋亡信号的见解发生了显着变化。我们现在正与NSCLC有关的分层治疗方法发生范式转变。这种思想转变的核心是不断出现的知识，即即使是大多数耐药性癌症也都具有功能性死亡途径，并且至关重要的是，这种途径可以有效参与，从而带来临床益处。这篇综述将总结NSCLC中线粒体凋亡途径功能障碍的当前知识，以及如何以个性化方式利用下一代靶向疗法来利用凋亡信号的不足来改善临床结果并预测治疗获益。

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《The EPMA journal.》 |2012年第1期|共8页
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Dean A Fennell; Charles Swanton;
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中图分类预防医学、卫生学;
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1. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression [J] . Michael G. Edwards, Katherine Vandervest, John Arcaroli, Biology Open . 2013,第7期

机译：hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中的抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶点）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用
2. Knockdown of TC-1 enhances radiosensitivity of non-small cell lung cancer via the Wnt/???2-catenin pathway Knockdown of TC-1 enhances radiosensitivity of non-small cell lung cancer via the Wnt/???2-catenin pathway Knockdown of TC-1 enhances radiosensitivity of non-small cell lung cancer via the Wnt/???2-catenin pathway [J] . Dapeng Wu, Wei Yan, Lei Li Biology Open . 2016,第4期

机译：TC-1的抑制通过Wnt /β2-catenin途径增强非小细胞肺癌的放射敏感性TC-1的抑制通过Wnt /β2-catenin途径增强非小细胞肺癌的放射敏感性TC-1的抑制通过Wnt /β2-catenin途径增强非小细胞肺癌的放射敏感性
3. Analysis of Real-World Data to Investigate the Impact of Race and Ethnicity on Response to Programmed Cell Death-1 and Programmed Cell Death-Ligand 1 Inhibitors in Advanced Non-Small Cell Lung Cancers [J] . Kristin L. Ayers, Whitney Jappe, Zongzhi Liu, The oncologist . 2021,第7期

机译：现实世界数据分析，探讨种族和种族对响应编程的细胞死亡-1和编程的细胞死亡 - 配体1抑制剂在先进的非小细胞肺癌中的影响
4. A proteomic signature of relapse-related death predicting clinical outcome in human non-small cell lung cancer [C] . Kiyoshi Yanagisawa M.D., Shuta Tomida, Yukako Shimada, ASMS Conference on Mass Spectrometry and Allied Topics . 2006

机译：复发相关死亡的蛋白质组学特征预测人非小细胞肺癌临床结果
5. The role of NAD(P)H:quinone oxidoreductase 1 in non-small cell lung cancer tumorigenesis and lung cancer stem cell maintenance [D] . Madajewski, Brian. 2016

机译：NAD（P）H：醌氧化还原酶1在非小细胞肺癌的发生和肺癌干细胞维持中的作用
6. Unlocking Pandoras box: personalising cancer cell death in non-small cell lung cancer [O] . Dean A Fennell, Charles Swanton 2012

机译：解锁潘多拉魔盒：个性化非小细胞肺癌中的癌细胞死亡
7. Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer [O] . Dean A Fennell, Charles Swanton 2012

机译：解锁潘多拉魔盒：个性化非小细胞肺癌中的癌细胞死亡

Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer

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