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首页> 外文期刊>Pneumonia. >Prevalence, pathogenesis, therapy, and prevention of cardiovascular events in patients with community-acquired pneumonia
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Prevalence, pathogenesis, therapy, and prevention of cardiovascular events in patients with community-acquired pneumonia

机译：社区获得性肺炎患者的患病率，发病机制，治疗和心血管事件的预防

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It is now well recognised that cardiac events occur relatively commonly in patients with acute community-acquired pneumonia. While these events are more frequent in patients with underlying risk factors—such as those with underlying chronic cardiovascular and respiratory comorbidities, the elderly, and in nursing home residents—they also occur in patients with no underlying risks other than severe pneumonia. Recent research elucidating the underlying pathogenic mechanisms related to these cardiac events has indicated a probable role for platelet activation, which is possibly exacerbated by pneumolysin in the case of pneumococcal infections. This, in turn, has resulted in the identification of possible therapeutic strategies targeting platelet activation, as well as the cardio-toxic activity of pneumolysin. These issues represent the primary focus of the current review.
机译：现在众所周知，急性事件在急性社区获得性肺炎患者中相对常见。尽管这些事件在具有潜在危险因素的患者（例如具有潜在慢性心血管和呼吸系统合并症的患者，老年人和疗养院居民）中更为常见，但它们也发生在除了严重肺炎之外没有其他潜在危险的患者中。最近的研究阐明了与这些心脏事件相关的潜在致病机制，表明了血小板活化的可能作用，在肺炎球菌感染的情况下，肺炎球菌溶血素可能会加剧血小板活化。反过来，这导致确定了针对血小板活化以及肺炎球菌溶血素的心脏毒性活性的可能的治疗策略。这些问题是当前审查的主要重点。

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