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Community-acquired pneumonia in the United Kingdom: a call to action

机译:英国社区获得性肺炎:呼吁采取行动

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Pneumococcal disease has a high burden in adults in the United Kingdom (UK); however, the total burden is underestimated, principally because most cases of community-acquired pneumonia (CAP) are non-invasive. Research into pneumonia receives poor funding relative to its disease burden (global mortality, disability-adjusted life years, and years lived with disability), ranking just 20 out of 25 for investment in infectious diseases in the UK. The current accuracy of data for establishing incidence rates is questionable, and it is a reflection of the paucity of research that much of the background information available derives from nearly 30?years ago. Given the relationship between CAP and mortality (pneumonia accounts for 29,000 deaths per annum in the UK, and 5–15% of patients hospitalised with CAP die within 30?days of admission), and the increasing threat of antimicrobial resistance associated with inappropriate antibiotic prescribing, such neglect of a highly prevalent problem is concerning. In this Call to Action, we explore the poorly understood burden of CAP in the UK, discuss the importance of an accurate diagnosis and appropriate treatment, and suggest how national collaboration could improve the management of an often life-threatening, yet potentially preventable disease.
机译:肺炎球菌病在英国(英国)的成年人中负担很重;但是,总负担被低估了,主要是因为大多数社区获得性肺炎(CAP)病例都是非侵入性的。相对于其疾病负担(全球死亡率,残疾调整的生命年和残障人士的寿命),对肺炎的研究获得的资金很少,在英国的传染病投资中,仅占25个中的20个。目前用于确定发病率的数据的准确性令人怀疑,这反映了研究的匮乏,因为许多可用的背景信息来自近30年前。考虑到CAP与死亡率之间的关系(在英国,肺炎每年导致29,000例死亡,住院的CAP住院患者中有5-15%的患者在入院后30天之内死亡),以及抗生素处方不当引起的抗菌素耐药性威胁日益增加,这种对高度普遍问题的忽视是令人担忧的。在本号召性用语中,我们探讨了英国对CAP负担不甚了解的问题,讨论了准确诊断和适当治疗的重要性,并提出了国家合作如何改善对经常威胁生命但可能可预防的疾病的管理。

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