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首页> 外文期刊>The EPMA journal. >Drug delivery systems: Advanced technologies potentially applicable in personalized treatments
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Drug delivery systems: Advanced technologies potentially applicable in personalized treatments

机译:药物输送系统:可能适用于个性化治疗的先进技术

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Abstract Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.
机译:摘要先进的药物输送系统(DDS)为药物管理带来了不可估量的好处。在过去的三十年中,已经提出了新的方法来开发用于药物递送的新型载体。在这篇综述中,我们基于旨在为多种高度流行的疾病(例如癌症和糖尿病)创造个性化治疗的多学科方法,描述了该领域的一般概念和新兴研究。这篇评论由两部分组成。第一部分概述了当前可用的药物输送技术,包括有关这些系统开发的简要历史以及所应用的一些研究策略。第二部分提供有关使用刺激反应性聚合物的最先进药物输送装置的信息。描述了使用可控的自由基聚合策略合成它们。从创建个性化医疗解决方案的角度来看,可以预见的是,新的有效的量身定制的DDS将会在不久的将来出现,这是由不同的跨学科科学知识产生的。

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