Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?

Olga Golubnitschaja; Kristina Yeghiazaryan; Josef Flammer

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Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?

机译：受青光眼病理影响的关键分子途径：预测性诊断可能吗？

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Prediction and prevention of glaucoma. Neurodegenerative eye disease glaucoma is the second leading cause of blindness with estimated 67 million patients worldwide. Molecular pathomechanisms of glaucoma demonstrate both a considerable overlap with and remarkable particularities compared to other neurodegenerative disorders e.g. Alzheimer’s disease. Identification of pathology-specific biomarker-sets is essential to develop advanced diagnostic approaches and personalised patients’ treatment. Subcellular imaging and expression patterns in blood as the reliable platform for early/predictive glaucoma diagnosis. Following key pathways are affected in glaucoma pathology: stress response, apoptosis and DNA-repair, adhesion, blood-brain-barrier-breakdown, tissue remodelling, transcription regulation, multidrug resistance and energy metabolism.

机译：青光眼的预测和预防。神经退行性眼病青光眼是失明的第二大主要原因，全世界估计有6700万患者。与其他神经退行性疾病，例如青光眼相比，青光眼的分子病理机制显示出与之相当的重叠和显着的特殊性。阿尔茨海默氏病。识别特定于病理的生物标志物集对于开发先进的诊断方法和个性化患者治疗至关重要。血液中的亚细胞成像和表达模式是早期/预测性青光眼诊断的可靠平台。青光眼病理学中以下主要途径受到影响：应激反应，细胞凋亡和DNA修复，黏附，血脑屏障破坏，组织重塑，转录调控，多药耐药性和能量代谢。

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《The EPMA journal.》 |2010年第2期|共8页
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Olga Golubnitschaja; Kristina Yeghiazaryan; Josef Flammer;
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中图分类预防医学、卫生学;
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Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?

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