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首页> 外文期刊>The EPMA journal. >Alzheimer’s disease: diagnostics, prognostics and the road to prevention
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Alzheimer’s disease: diagnostics, prognostics and the road to prevention

机译：阿尔茨海默氏病：诊断，预测和预防之路

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Alzheimer’s disease (AD) presents one of the leading healthcare challenges of the 21st century, with a projected worldwide prevalence of >107 million cases by 2025. While biomarkers have been identified, which may correlate with disease progression or subtype for the purpose of disease monitoring or differential diagnosis, a biomarker for reliable prediction of late onset disease risk has not been available until now. This deficiency in reliable predictive biomarkers, coupled with the devastating nature of the disease, places AD at a high priority for focus by predictive, preventive and personalized medicine. Recent data, discovered using phylogenetic analysis, suggest that a variable length poly-T sequence polymorphism in the TOMM40 gene, adjacent to the APOE gene, is predictive of risk of AD age-of-onset when coupled with a subject’s current age. This finding offers hope for reliable assignment of disease risk within a 5-7?year window, and is expected to guide enrichment of clinical trials in order to speed development of preventative medicines.
机译：阿尔茨海默氏病（AD）提出了21世纪的主要医疗保健挑战之一，预计到2025年，全世界的患病率将超过1.07亿例。虽然已经鉴定出生物标志物，但可能与疾病进展或亚型相关，以进行疾病监测或鉴别诊断，至今尚无用于可靠预测晚期发病风险的生物标志物。可靠的预测生物标记物的缺乏，加上该疾病的毁灭性，使得通过预测，预防和个性化医学将AD置于重点关注的高度位置。使用系统发育分析发现的最新数据表明，与APOE基因相邻的TOMM40基因中可变长度的poly-T序列多态性可预测AD发病年龄，再加上受试者的当前年龄。这一发现为在5-7年内可靠地分配疾病风险提供了希望，并有望指导丰富的临床试验，以加快预防药物的开发。

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