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首页> 外文期刊>The Internet Journal of Pharmacology >An Antibacterial Drug Utilization Study at Surgical Units of Shree Sayaji General Hospital, Vadodara, Gujarat, India
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An Antibacterial Drug Utilization Study at Surgical Units of Shree Sayaji General Hospital, Vadodara, Gujarat, India

机译：印度古吉拉特邦瓦多达拉Shree Sayaji总医院外科部门的抗菌药物利用研究

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IntroductionAntibacterials account for nearly 20% of all new and repeat prescriptions each year and over 50% of total value of drugs sold in India. Irrational prescribing of these drugs is known to take place throughout the world. In developing countries like India, this may be extremely important as the funds available for healthcare budget may be quite limited. It has been observed that 64% of the total antibacterials prescribed are either not indicated or inappropriate in terms of drug selection or dosage or therapeutic basis. It is clear that if this can be improved, then misuse of antibacterial can be avoided to a large extent. However before suggesting any change, it is necessary to evaluate the existing base line practice which can be done using data on prescriptions and prescribing practices with the help of a drug utilization study. This may therefore, help us to identify the problems, suggest the remedial measures and promote rational use. So, to analyze the same at Shree Sayaji General Hospital (SSG Hospital), a tertiary level teaching hospital, Vadodara, Gujarat in six surgical units this study was carried out. AimPrimary aim of the study was to evaluate the extent and pattern of use of antibacterial agents, in in-patients of six surgical units of SSG Hospital, Vadodara with secondary aim to determine the type of antibacterial used along with their purpose of use, route of administration, duration and supply.Material and MethodsThis was a prospective study with duration of 6 months from March, 2006 to August, 2006. Six units of general surgery with one ward for each of them were selected for the work. Fifty patients admitted to each unit during the time of the study were randomly selected for the work making total number of 300 cases. Patients had been visited thrice weekly for recording all the relevant details of the case (s) in a pre-validated, predefined performa for a consequent analysis. The performa included diagnosis, date of admission, operation (if any) and discharge. Along with these, drug utilization details that included trade name of the drug(s), dose, route and frequency of administration, duration of treatment, indications (whether prophylactic or curative), source (hospital supply / market purchase) were also collected. Results of the culture and sensitivity tests if performed along with any other laboratory tests were also recorded. Adverse drug reactions were also monitored. The data obtained was analyzed for important prescribing indicators i.e. common surgical conditions observed amongst indoor patients in general surgery department, groups of antimicrobial agents used commonly, Individual antimicrobial agents used commonly, number of patients where antibacterial drugs were given orally or parenterally, purpose for the antibacterial drug use (prophylactic/curative) etc. ResultsAmong 300 indoor patients, there were 228 males (76%) as compared to 72 females (24%). It was observed that antimicrobial drugs were prescribed in all 300 indoor patients in surgery. Showing selection of antibiotics for the indoor patients of six surgical units of SSG Hospital, Vadodara, Gujarat. Although no significant difference was observed in the antimicrobials prescribed by oral and parenteral route, yet out of the 1051 drugs prescribed, more no. of antimicrobials were given through oral route 53% (552) than through parenteral route 47%(499). In596(54%) out of 1051(100%) prescriptions, the use of antimicrobial agents was indicated for prophylaxis while remaining 482(46%) out of 1051 prescriptions the intention appeared to be curative for an existing or hospital acquired infections. Out of 300 patients culture and sensitivity test was done only in 3.1% of cases only. Out of 1051 total prescriptions, 86.6% (911) drug were supplied from government setup as compared to of 13.3% (140) drugs, which the patients were directed to buy from the market.Conclusion The pooled data of all the patients show that antibacterial agent
机译：引言每年，抗菌药物占所有新处方和重复处方的近20％，占印度销售药品总价值的50％以上。这些药物的不合理处方在世界范围内都是众所周知的。在印度这样的发展中国家，这可能非常重要，因为可用于医疗保健预算的资金可能非常有限。已经观察到，在药物选择，剂量或治疗基础方面，未标明处方的全部抗菌药物的64％或不合适。显然，如果可以改善这一点，则可以在很大程度上避免滥用抗生素。但是，在建议进行任何更改之前，有必要评估现有的基线实践，该实践可使用处方数据和处方实践在药物利用研究的帮助下完成。因此，这可能有助于我们发现问题，提出补救措施并促进合理使用。因此，本研究在位于古吉拉特邦瓦多达拉的三级教学医院Shree Sayaji总医院（SSG医院）的六个手术单元中进行了同样的分析。目的本研究的主要目的是评估在瓦多达拉SSG医院六个手术室的住院患者中使用抗菌剂的程度和方式，其次要目的是确定所用抗菌剂的类型及其使用目的，途径。材料，方法这是一项前瞻性研究，从2006年3月至2006年8月为期6个月。选择了6个普通外科，每个外科都有一个病房。在研究期间，随机选择了进入该病房的50名患者作为研究对象，总计300例。每周三次拜访患者，以预先验证的，预定的执行方式记录病例的所有相关细节，以进行后续分析。表现包括诊断，入院日期，手术（如果有）和出院。除此之外，还收集了药物利用的详细信息，其中包括药物的商品名，剂量，给药途径和频率，治疗时间，适应症（无论是预防性还是治疗性），来源（医院供应/市场购买）。还记录了培养和敏感性测试的结果（如果与其他实验室测试一起进行的话）。还监测了药物不良反应。对获得的数据进行了分析，以寻找重要的处方指标，例如，在普通外科部门的室内患者中观察到的常见手术条件，常用的抗菌剂组，常用的单个抗菌剂，口服或胃肠外给予抗菌药物的患者数结果在300名室内患者中，男性228例（76％），女性72例（24％）。观察到在所有300名室内手术患者中均开了抗菌药物。正在显示古吉拉特邦瓦多达拉SSG医院六个手术室的室内患者的抗生素选择。尽管口服和肠胃外途径使用的抗菌药物未见明显差异，但在处方的1051种药物中，没有。口服途径给予抗菌药物的比例为53％（552），而肠胃外途径给予的抗菌药物的比例为47％（499）。在1051（100％）份处方中，有596（54％）指示使用抗菌剂进行预防，而在1051处方中，其余482（46％）的意图是对现有或医院获得的感染有治愈作用。在300名患者中，仅在3.1％的病例中进行了培养和敏感性测试。在1051份总处方中，政府机构提供了86.6％（911）药物，而患者直接从市场上购买了13.3％（140）药物。结论所有患者的汇总数据表明，抗菌药物代理人

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