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首页> 外文期刊>The Internet Journal of Pharmacology >Fixed Drug Eruption Due to Tinidazole: 2 Case Reports and Review of Literature
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Fixed Drug Eruption Due to Tinidazole: 2 Case Reports and Review of Literature

机译：替硝唑引起的固定药物喷发：2例报告并文献复习

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摘要

Fixed Drug Eruption (FDE) is a common type of drug eruption characterized by single or multiple skin lesions which occur at the same site each time the drug is administered. FDEs though usually not fatal, can cause cosmetic embarrassment if exposed parts are affected due to recurrence of the reaction on the previously affected site and residual hyperpigmentation. Genital fixed drug eruption in particular, is the cause for apprehension among the sufferers. FDE usually occurs within hours of administration of the offending agent. Nitroimidazoles including tinidazole have been used for anaerobic infections especially in intestinal amoebiasis, without much side effects, but may cause FDEs. We report 2 (two) cases of FDE due to tinidazole attending dermatology out patient clinic. The first one is a case of FDE on the glans penis and the second one is a case of FDE on the lips and trunk. In both the cases tinidazole was advised to stop. The cases were managed with steroid and anti histamines. Both the patient and famlily members were counseled for possible ADRs occurred due to tinidazole intake and advised to avoid tinidazole and any self medication and also to notify to physicians physicians regarding such reactions in future.
机译：固定药物喷发（FDE）是药物喷发的一种常见类型，其特征是每次给药时都在同一部位发生单个或多个皮肤损伤。 FDE虽然通常不会致命，但是如果裸露的部分由于先前受影响部位的反应重复发生和残留的色素沉着过多而受到影响，则可能引起美容尴尬。特别是生殖器固定药的喷发是导致患者恐惧的原因。 FDE通常在违规药物给药后数小时内发生。包括替硝唑在内的硝基咪唑类药物已用于厌氧菌感染，尤其是在肠阿米巴病中，无太多副作用，但可能引起FDE。我们报告了2（两）例由于替硝唑在患者诊所就诊的皮肤病引起的FDE病例。第一个是龟头阴茎上的FDE，第二个是嘴唇和躯干上的FDE。在这两种情况下，均建议停止使用替硝唑。病例接受类固醇和抗组胺药治疗。患者和家属均被告知可能因摄入替硝唑而发生了不良反应，并建议避免使用替硝唑和任何自用药，并在将来将此类反应告知医师。

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