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Lipid Lowering Effect Of Aqueous Leaf Extract Of Spondias Mombin Linn

机译：刺槐叶提取物的降血脂作用

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The effect of aqueous leaf extract of Spondias mombin Linn on serum lipid profile of rabbits was studied. Preliminary phytochemical analysis was also carried out on the extract. Forty-eight female rabbits, randomly distributed into 4 groups of 12 rabbits each, were orally administered with the extract twice daily for 12 days. The groups I-III animals were administered with the extract at 250mg/kg, 500mg/kg and 750mg/kg body weights respectively, while the remaining group served as the control. The serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), atherogenic index and free fatty acid (FFA) levels were determined from blood samples collected on the 0th, 4th, 8th and 12th days of extract administration. The results showed that extract administration significantly (p<0.05) reduced serum TC, TG and LDL-C concentrations. The administration of the leaf extract on the other hand, did not significantly (p<0.05) reduce serum HDL-C in groups I and II animals. FFA concentration and the atherogenic indexes of the animals had no significant differences between tests and control. These findings may be of clinical importance to individuals at risk of cardiovascular disease. Introduction Spondias mombin Linn, commonly known as Hog plum in English language and ‘Ijikara' by the people of southeastern Nigeria, is a medium sized but occasionally large tree. It is widely found in tropical America, Asia and Africa, and has been recently cultivated in commercial quantities in Mexico (Leon and Shaw, 1990). It may be propagated by seeds but is usually grown from stem cuttings. The tree is widely grown for its yellow pleasant pulp-like fruits, or used as live fence posts and for provision of shade. The fruits are popular for eating and the extracted juice is used to prepare ice cream, cool beverages, jam and wine such as ‘Vino de Taperiba' (Morton, 1987). The plant is reported to have multiple therapeutic properties. The bark when steeped in water gives a decoction used by women in rural areas as a vaginal douche, and is also drunk to cure ailments of reproductive system. The decoction of the astringent bark also serves as emetic, a remedy for diarrhea, dysentery, haemorrhoids and also as a treatment for gonorrhoea (Martinez, 2000). The plant leaves have been reported to contain antiviral ellagitannins and caffeoyl esters and antibacterial and molluscicidal phenolic acids (Corthout et al, 1994). The leaves have also been demonstrated to have antihelmintic (Ademola et al, 2005) and abortifacient (Offiah and Anyanwu, 1989) activities.In traditional medical practice of southern Nigeria, fresh boiled aqueous leaf extract of S. mombin is used to treat dizziness especially after childbirth, while the bark is used to cook for mothers after delivery (Onwuka, 1992). The leaves are commonly fed to pregnant domestic animals to hasten littering or to expel placenta after successful littering (Nzegbule and Meregini, 1999). All these medicinal uses notwithstanding, the plant leaves are among the tropical browse species fed to goats and sheep in Nigeria (Onwuka, 1992).Given the traditional, medicinal and domestic uses of S. mombin, there is a need for elaborate studies of the physiological and biochemical aspects of the plant. the present communication describes studies of the effects of this ethnic drug source on the serum lipid profile of rabbits. Materials And Methods Collection, Identification and Extraction of Plant MaterialsApparently healthy fresh leaves of S. mombin were obtained from the yam barn of the National Root Crop Reasearch Institute, Umudike, Nigeria. They were authenticated by a plant taxonomist at the Department of Plant Science and Biotechnology, Imo State University, Owerri, Nigeria. The leaves were dried to constant weight at 60 ° C in a laboratory oven. They were later ground into fine powder with the aid of a clean dry electric grinder (ED-5 Arthur Th
机译：研究了刺槐水提取物对家兔血脂的影响。还对该提取物进行了初步植物化学分析。将48只雌性兔子随机分成4组，每组12只，每天两次口服提取物，共12天。给I-III组动物分别以250mg / kg，500mg / kg和750mg / kg体重的提取物施用，而其余组作为对照。从血样中确定血清总胆固醇（TC），高密度脂蛋白胆固醇（HDL-C），三酰甘油（TG），低密度脂蛋白胆固醇（LDL-C），动脉粥样硬化指数和游离脂肪酸（FFA）水平在提取物给药的第0、4、8和12天收集。结果表明，提取物给药显着（p <0.05）降低了血清TC，TG和LDL-C浓度。另一方面，叶提取物的施用并未显着（p ＜0.05）降低I组和II组动物的血清HDL-C。动物的FFA浓度和动脉粥样硬化指数在试验和对照之间没有显着差异。这些发现对于有患心血管疾病风险的个体可能具有临床重要性。简介Spondias mombin Linn（英语：Songdias mombin Linn）是一棵中等大小但偶尔很大的树，在尼日利亚东南部通常被称为“猪李”和“ Ijikara”。在热带美洲，亚洲和非洲广泛发现它，最近在墨西哥以商业化数量进行了种植（Leon and Shaw，1990）。它可以通过种子繁殖，但通常是从茎插中生长出来的。该树因其黄色宜人的果肉状水果而被广泛种植，或用作活篱笆柱和提供遮荫。水果很受欢迎，提取的果汁用于制备冰淇淋，凉爽的饮料，果酱和葡萄酒，例如“ Vino de Taperiba”（莫顿，1987年）。据报道该植物具有多种治疗特性。将树皮浸入水中后，可制成汤剂，用于农村地区的妇女，作为阴道冲洗液，也可饮用以治疗生殖系统疾病。收敛性树皮的汤剂还可以作为催吐药，腹泻，痢疾，痔疮的药物，也可以治疗淋病（Martinez，2000）。据报道，植物叶片中含有抗病毒鞣花单宁和咖啡酰酯以及抗菌和杀软体酚酸（Corthout等，1994）。叶片还被证明具有抗蠕虫作用（Ademola等，2005）和流产（Offiah and Anyanwu，1989）。在尼日利亚南部的传统医学实践中，新鲜煮沸的桑叶链球菌水合叶提取物用于治疗头晕。分娩后，树皮用于分娩后的母亲做饭（Onwuka，1992）。叶子通常被喂给怀孕的家畜，以加快乱抛垃圾或在乱抛垃圾后驱赶胎盘（Nzegbule and Meregini，1999）。尽管有所有这些药用用途，但植物叶子仍是尼日利亚饲喂山羊和绵羊的热带浏览物种之一（Onwuka，1992）。鉴于传统的，药用和家庭用途的苦瓜链球菌，有必要对它们进行详尽的研究。植物的生理和生化方面。本通讯描述了这种民族药物来源对兔血清脂质谱的影响的研究。材料和方法植物材料的采集，鉴定和提取从尼日利亚根特国家作物研究中心的山药仓中获得的表观健康的桑叶链霉菌新鲜叶子。它们由尼日利亚Owerri Imo州立大学植物科学与生物技术系的植物分类学家认证。将叶片在实验室烤箱中于60°C干燥至恒重。随后，借助干净的干式电动研磨机（ED-5 Arthur Th）将它们研磨成细粉。

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