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首页> 外文期刊>The Internet Journal of Pharmacology >Anti-inflammatory evaluation of methanol extract and aqueous fraction of the leaves of Anthocleista djalonensis A. Chev (Gentianaceae).
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Anti-inflammatory evaluation of methanol extract and aqueous fraction of the leaves of Anthocleista djalonensis A. Chev (Gentianaceae).

机译：美洲ja（Antiancleista djalonensis A. Chev）（龙胆科）甲醇提取物和叶片水部分的抗炎性评估。

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The effects of the methanol extract (crude) and aqueous fraction of Anthocleista djalonensis on acute inflammation were examined. Oral administration of the methanol extract showed acute anti-inflammatory activity against Carrageenan induced paw edema in rats although not too significantly different (P>0.05) from the control at 250 mg/kg and 500 mg/kg. The aqueous fraction of the methanol extract significantly inhibited (P < 0.05) carrageenan induced paw edema in rats at 500 mg/kg. Significant activity against Dextran induced paw edema in rats was exhibited by both methanol extract (P< 0.01) and aqueous fractions (P< 0.05) when administered orally at 250 mg/kg and 500 mg/kg. The dry powdered leaf was found to contain alkaloids, glycosides, saponins and tannins. It is revealed from the screening model used that the methanol extract and aqueous fraction of this plant possesses acute anti-inflammatory activity. Introduction The use of plants to treat ailments is as old as antiquity. Records of humans using plants to treat diseases have been recorded as far back as 6000 to 4000 years ago when Ayurvedic physicians started treating tumors with extracts from Vinca roseus [1]. The use of medicinal herb in the treatment and prevention of diseases is attracting attention by scientists world wide [2]. The use of traditional medicine and medicinal plants in most developing countries, as a normotive basis for the maintenance of good health, has been widely observed [3]. Anthocleista djalonensis commonly called “Fartanlafla” in Mali [4], “Osuo” in Bayelsa (Southern Nigeria) is used traditionally for the treatment of various diseases, the plant is known for antipyretic, stomachic, analgesic and purgative actions [56], the aqueous extract was reported to produce a rise in blood pressure of cats and an increase in tone and amplitude of movement of rabbit duodenal preparations. The root decoction has been used in the treatment of diabetes mellitus. Herbalists claim a high percentage of cures in their diabetic patients treated with it [7].Traditionally, the leaves are reputed to be used for the treatment of malaria and jaundice [8]. The bark is used as a purgative in small doses as large doses are considered toxic. According to the Mendi ethnomedicine, when the tree is used as firewood, the people sitting around the fire become sick [9].The decoction of the leaves is drunk in Sierra Leone as treatment for jaundice, in Ivory Coast the root is used as a diuretic, vigorous purgative, poison antidote, treatment for leprosy, as an emmenagogue and in the treatment of edemas and elephantiasis of the scrotum. The root decoction is taken against chest pain, constipation and stomach pain [10]. The study was therefore aimed at investigating the anti-inflammatory activity of the leaf extracts with a view to justifying the use of the plant in the treatment of oedemas and elephantiasis of the scrotum. Materials and Methods Plant collection and identificationThe fresh leaves of Anthocleista djalonensis were collected in Ugbowo area of Benin city, Edo State, Nigeria, in March 2008 and identified and authenticated by Dr. B.A Ayinde of the Department of Pharmacognosy, University of Benin, Benin City, Nigeria, were a voucher specimen has been deposited. Dried leaves of Anthocleista djalonensis were reduced to a fine powder with a mechanical grinder, filtered, and the fine powder was stored in a non-toxic polyethylene bag.Extraction and fractionation of plantThe fine powder (600 g) was marcerated in 2.5 litres methanol for 48 hours, filtered, concentrated in a rotary evaporator, weighed (84 g) and stored. Forty grams of the concentrate was dissolved in methanol and successively and exhaustively partitioned into various fractions using n-hexane, chloroform and water. The various fractions were evaporated to dryness, weighed and stored in the fridge.Phytochemical screeningQualitative assay, for the presence of plant secondary metabolites such as carbohydrate, alkaloi
机译：考察了甲醇提取物（粗制物）和美洲按蚊的含水部分对急性炎症的影响。口服甲醇提取物显示出对角叉菜胶诱导的大鼠足水肿的急性抗炎活性，尽管在250 mg / kg和500 mg / kg时与对照组没有太大差异（P> 0.05）。甲醇提取物的水部分以500 mg / kg的浓度可显着抑制（P <0.05）角叉菜胶诱发的大鼠足水肿。当以250 mg / kg和500 mg / kg口服给药时，甲醇提取物（P <0.01）和水部分（P <0.05）均表现出对大鼠右旋糖酐诱导的爪水肿的显着活性。发现干粉叶含有生物碱，糖苷，皂苷和单宁酸。从所用的筛选模型表明，该植物的甲醇提取物和水部分具有急性抗炎活性。简介使用植物治疗疾病的历史可追溯至古代。早在6000到4000年前，当印度草药医生开始使用长春花提取物治疗肿瘤时，已有人类使用植物治疗疾病的记录[1]。在世界范围内，使用草药来治疗和预防疾病正引起人们的关注[2]。在大多数发展中国家，传统医学和药用植物的使用是维持良好健康的一种动力基础[3]。传统上，Anthocleista djalonensis在马里被称为“ Fartanlafla” [4]，在Bayelsa（尼日利亚南部）被称为“ Osuo”，传统上用于治疗各种疾病，该植物以解热，胃，镇痛和泻药作用而闻名[56]，据报道，水提取物可引起猫的血压升高，兔十二指肠制剂的运动音调和振幅增加。根汤已用于治疗糖尿病。中医师声称用它治疗的糖尿病患者治愈率很高[7]。传统上，叶子被认为可用于治疗疟疾和黄疸[8]。由于认为大剂量有毒，小剂量的树皮可用作泻药。根据Mendi的民族医学，当树木用作木柴时，坐在火堆旁的人会生病[9]。在塞拉利昂，叶子的汤剂被喝成黄疸药，在象牙海岸，其根被用作木柴。利尿剂，强泻药，解毒药，麻风病治疗剂，治疗遗精，阴囊水肿和象皮病。根汤可预防胸痛，便秘和胃痛[10]。因此，该研究旨在研究叶提取物的抗炎活性，以证明将该植物用于治疗阴囊水肿和象皮病。材料和方法植物的收集和鉴定2008年3月，在尼日利亚的江户州贝宁市的Ugbowo地区收集了Anthocleista djalonensis的新鲜叶子，并经贝宁大学贝宁大学药理学系的BA Ayinde博士鉴定和鉴定。尼日利亚的一个凭证标本已经存放。用机械研磨机将干燥的Anthocleista djalonensis的叶子切成细粉，过滤，然后将细粉存储在无毒的聚乙烯袋中。提取和分馏植物将细粉（600 g）在2.5升甲醇中切碎， 48小时，过滤，在旋转蒸发仪中浓缩，称重（84g）并储存。将40克浓缩物溶解在甲醇中，并使用正己烷，氯仿和水依次彻底地分配成各种馏分。将各种馏分蒸发至干，称重并保存在冰箱中。植物化学筛选定性分析，以检测是否存在植物次生代谢产物，如碳水化合物，碱

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