Phytochemistry And Antimicrobial Screening Of Stem Bark Of Murraya Koenigii(Linn) Spreng

Subin Mary Zachariah; P.M. Muthumani; K.V. Ramaseshu

摘要

Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand for plant based medicines , health products, pharmaceuticals , food supplements, cosmetics etc.there is no evidence regarding the antimicrobial studies in petroleum ether, chloroform ,alcohol extracts and acetone extracts studied together and even the isolated compounds of Murraya koeniggii compared with the synthetic carbazole alkaloids . A review of chemical constituents present in stem bark of Murraya koenigii and their search for antimicrobial activity is given in the present article .Anti-bacterial activity and antifungal activity of Murraya koenigii were studied against Staphylococcus aureus and Candida albicans respectively. The maximum inhibitory zone of inhibition of coumarin was against (22mm) Bacillus substillus and Candida albicans (21 mm). Introduction Carbazole [1] alkaloids represent a new and interesting variant in the number of existing indole alkaloids which in the past have yielded several important drugs. A rich and rewarding source of carbazole alkaloids has been the Indian curry leaf plant Murraya koenigii (Spreng) Rutaceae. All plant parts of this plant including root, stem, leaves and fruits yielded carbazole alkaloids. Although search has been for the presence . In view of the presence of various phytochemical constituents and pharmacological properties of the plant Murraya koenigii Spreng, it was decided to work on the stem of Murraya koenigii Spreng, which is widely used in indigenous medicine. The coarse powder on extraction with petroleum ether, chloroform and acetone showed the presence of alkaloids and coumarins and investigated for antibacterial and antifungal activity. Murraya koenigii is an aromatic more or less deciduous shrub or a small tree up to 6m in height and 15-40 cm in diameter found throughout India up to an altitude of 1,500m commonly in forests often as gregarious under-growths. The Plant Murraya Koenigii belongs to family Rutaceae, commonly called “Curry leaf plant” in English and locally known as “Karivepu”. It is cultivated for its aromatic leaves. The plant used as Tonic, stomachic and carminative. Fresh juice of the root is taken to relieve pain associated with kidney. Leaves are used internally in dysentery and diarrhoea. The aqueous extracts of leaves,, when administered parenterally to female guinea pigs, not only raised the phagocytic index but also mobilized a greater number of leucocytes to take part in phagocytosis. PhytochemistryThe aqueous extract of M.koenigii leaves showed hypoglycaemic action in normal and alloxan diabetic dogs.(Narayana and Shastri,1975) The essential oil from M.koenigii leaves showed antibacterial effect against B.substillus, Staph. aureus, C.pyogenes,M.tuberculosis(Bhakuni et al.,1969) but found to be inactive. The pure oil was active against the first three organisms even at a dilution of 1:500 (Goutam and Purohit 1974).Khosa ( 7-methoxy-8 (1,2-dihydroxy-3-methyl-3-butenyl) coumarin and 7-methoxy-8-formyl coumarin obtained from the leaves of M.paniculata exhibited antibacterial activity against E.coli and B.substilus and antifungal activity against Aspergillus flavus, Pallicularia sasaki, Fusarium vasiinfectum and Microsporum gypsum1-methoxy carbazolequinones for their potential cytotoxicity against MOLT-4 leukaemic and HOP-18 non small cell lung cancer cell lines. The cytotoxicity of pyranocarbazole was found to be very active against leukaemia and colon cancer cell lines. The petrol extract of leaves led to the isolation of 3, 5, 6, 8, 3’, 4’, 5’-heptamethoxy flavone and murrayatin together with auraptenol and meranzine hydrate. A new coumarin murrayone ( was isolated from the leaves of M.exotica.An optically active mahanimbine was isolated from the extract by Roy and Chakraborty et al.,1974.,curryanin by Dutta(Dutta,N.L,Quasim.C,Wadia,M.S,Indian Journal of chemistry,7,1969,307 et al.,in 1969).A new coumarin murrayon

机译：自人类文明开始以来，植物一直是重要的药物来源之一。对基于植物的药物，保健品，药品，食品补充剂，化妆品等的需求不断增长。没有证据表明一起研究石油醚，氯仿，酒精提取物和丙酮提取物中的抗菌素研究，甚至没有分离出的Murraya koeniggii化合物。与合成咔唑生物碱比较。本文综述了紫茉莉（Murraya koenigii）茎皮中存在的化学成分及其对抗菌活性的研究。分别研究了紫茉莉（Murraya koenigii）对金黄色葡萄球菌和白色念珠菌的抗菌活性。香豆素的最大抑制区域是对枯草芽孢杆菌和白色念珠菌（21毫米）的抑制（22毫米）。简介咔唑[1]生物碱代表了现有吲哚生物碱的数量中一个新的有趣的变体，在过去，吲哚生物碱已产生了几种重要的药物。印度咖喱叶植物Murraya koenigii（Spreng）Rutaceae是咔唑生物碱的丰富而有益的来源。该植物的所有植物部分（包括根，茎，叶和果实）均产生咔唑生物碱。虽然一直在寻找存在。鉴于植物Murraya koenigii Spreng的各种植物化学成分的存在和药理特性，决定研究在土著医学中广泛使用的Murraya koenigii Spreng的茎。用石油醚，氯仿和丙酮萃取的粗粉显示出生物碱和香豆素的存在，并研究了其抗菌和抗真菌活性。 Murraya koenigii是一种或多或少的芳香性落叶灌木或一棵小树，高约6m，直径15-40 cm，遍布印度，最高海拔1,500m，通常在森林中生长，通常是群居的灌木丛。植物Murraya Koenigii属于芸香科，在英语中俗称“咖喱叶植物”，在当地被称为“ Karivepu”。因其芳香的叶子而栽培。该植物用作补药，胃药和胭脂红。取新鲜的根汁以减轻与肾脏有关的疼痛。叶子可用于痢疾和腹泻。当对雌性豚鼠肠胃外给药时，叶片的水提取物不仅提高了吞噬指数，还动员了更多的白细胞参与吞噬作用。植物化学在正常和四氧嘧啶糖尿病犬中，M.koenigii叶片的水提取物均具有降血糖作用。（Narayana和Shastri，1975）。金黄色葡萄球菌，结核分枝杆菌（M.tuberculosis）（Bhakuni et al。，1969），但没有活性。即使以1：500的稀释倍率，纯油也对前三种生物具有活性（Goutam和Purohit 1974）。科萨（7-甲氧基-8（1,2-二羟基-3-甲基-3-丁烯基）香豆素和7从M.paniculata的叶子获得的-甲氧基-8-甲酰基香豆素对大肠杆菌和枯草芽孢杆菌具有抗菌活性，并且对黄曲霉，Sasaki Pallicularia，镰刀镰刀菌和小孢子石膏具有抗真菌活性。1-甲氧基咔唑醌对MOLT具有潜在的细胞毒性-4白血病和HOP-18非小细胞肺癌细胞系，吡喃咔唑对白血病和结肠癌细胞系具有很强的细胞毒性，叶子的汽油提取物导致分离出3、5、6、8 ，3'，4'，5'-七甲氧基黄酮，墨累定，金乌烯醇和水合暗兰碱。等19 74.，Dutta的curryanin（Dutta，N.L，Quasim.C，Wadia，MS，Indian Journal of Chemistry，7，1969，307等，1969）。一种新的香豆素murrayon。

Phytochemistry And Antimicrobial Screening Of Stem Bark Of Murraya Koenigii(Linn) Spreng

摘要

著录项

相似文献

相关主题

期刊订阅