Antiepileptic drugs (AED's) depress abnormal neuronal discharges and raise the threshold for neural impulse propagation. They have been found to have therapeutic efficacy in neuropathic pain states. Carbamazepine(CZ) and phenytoin (PT) were the drugs of choice for treating trigeminal neuralgia for 40 plus years. These two agents have been largely replaced due to the introduction of many newer, better-tolerated, and safer antiepileptic drugs.
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