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首页> 外文期刊>The Internet Journal of Neurology >Aetiology of Co-morbid Psychiatric Disorders In Dystonia: A Biopsychosocial Hypothesis
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Aetiology of Co-morbid Psychiatric Disorders In Dystonia: A Biopsychosocial Hypothesis

机译：肌张力障碍合并精神疾病的病因学：一种生物社会心理假说

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Dystonias are a heterogeneous group of movement disorders characterised by involuntary, sustained contraction of antagonist muscles that causes repetitive movements or abnormal postures. Dystonia is a rare condition. Nonetheless, it is important due to the high morbidity patient's experience. Much of this morbidity results from disability associated with dystonic movement. However, it is less recognised that the frequent occurrence of co-morbid psychiatric conditions (40 - 75% of patients) in dystonia contributes to the morbidity of dystonia. While the pathophysiological basis of dystonic movement has been extensively investigated, little research into the aetiology of co-morbid psychiatric disorders has been performed. Here, a literature review was undertaken to define what psychiatric disorders occur in dystonia and to find studies that could be synthesised into a Bio-Psycho-Social model of the aetiology of psychiatric disorders in dystonia. Current research supports the hypothesis that psychiatric disorders in dystonia result from both the underlying neurobiological abnormality and psychosocial factors associated with disability and disfigurement. Introduction The dystonias are a heterogeneous group of movement disorders, characterised by involuntary, sustained contraction of antagonist muscles, which results in twisting and repetitive movements or abnormal postures.1 Dystonias are classified on the basis of the muscle groups affected, or by aetiology, as outlined in table 1.2 Age at onset can also be used to categorise patients, since it provides prognostic information, with early onset (under 26 years old) cases often becoming generalised while late onset (over 26 years old) dystonia remains focal.2
机译：肌张力障碍是一组运动障碍的异质性组，其特征是拮抗性肌肉非自愿地持续收缩，从而引起重复性运动或异常姿势。肌张力障碍是一种罕见的疾病。但是，由于患者的高发病率经验，这一点很重要。这种疾病的大部分是由于与肌张力障碍运动相关的残疾造成的。然而，很少有人认识到肌张力障碍中并存的精神病性疾病的频繁发生（占患者的40-75％）会导致肌张力障碍的发病。虽然对肌张力运动的病理生理基础进行了广泛的研究，但对共病精神病的病因学的研究很少。在这里，进行了文献综述，以定义在肌张力障碍中发生哪些精神疾病，并找到可以综合到肌张力障碍精神病的病因的生物心理社会模型中的研究。当前的研究支持以下假设：肌张力障碍中的精神疾病是由潜在的神经生物学异常以及与残疾和毁容有关的社会心理因素引起的。引言肌张力障碍是运动障碍的异质性组，其特征是拮抗性肌肉不自主地持续收缩，从而导致扭曲和重复性运动或姿势异常。1肌张力障碍是根据受影响的肌肉群或病因分类为表1.2概述了发病年龄也可以用于对患者进行分类，因为它可以提供预后信息，发病初期（26岁以下）的病例通常会变得普遍，而发病后期（26岁以上）的肌张力障碍仍然是重点2。

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