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首页> 外文期刊>The Internet Journal of Neurology >Epilepsy, Hypogonadotropic Hypogonadism, and Systemic Lupus Erythematosus
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Epilepsy, Hypogonadotropic Hypogonadism, and Systemic Lupus Erythematosus

机译：癫痫，促性腺功能低下症和系统性红斑狼疮

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We report on a patient with uncontrolled epilepsy, hypogonadotropic hypogonadism and systemic lupus erythematosus in a rural setting of the Eastern Cape, South Africa. Introduction Gonadal function is significantly affected in many acute and chronic systemic diseases. As the function of the testes and the ovaries is determined by the integrity of the hypothalamic–pituitary–gonadal axis, it is obvious that a systemic disease may affect one or more levels of the axis in such a manner that the gonadal dysfunction may have various clinical and laboratory manifestations. In this brief review, the most common disturbances seen in the main systemic diseases will be discussed, and the relationship between epilepsy, hypogonadotropic hypogonadism and systemic lupus erythematosus examined. Case Report A 23 year old male presented at Nelson Mandela Academic Hospital (Mthatha) with a longstanding history of uncontrolled epilepsy. He experienced up to 2 fits per day, which were generalised tonic-clonic. The patient claimed to be compliant on an unknown dose of carbamazepine and phenobarb, which he received at a peripheral clinic.According to his family the patient had a normal development as a young child, but at the age of 12 he developed a malar rash, and all developmental progression seized. This developmental delay was never brought under the attention of any health worker.On examination the patient was in a good general condition, with normal vital signs. A malar rash was evident. He had an abnormally short stature of 149 cm, no secondary sexual characteristics, and had only a right sided palpable testis. Systemic examination, including neurological, was within normal limits.
机译：我们报告在南非东开普省的一个农村地区患有癫痫，性腺功能低下性腺功能减退和系统性红斑狼疮的患者。简介性腺功能在许多急慢性系统性疾病中均受到显着影响。由于睾丸和卵巢的功能是由下丘脑-垂体-性腺轴的完整性决定的，因此很明显，全身性疾病可能以一种性腺功能障碍可能具有各种不同的方式影响轴的一个或多个水平临床和实验室表现。在这篇简短的综述中，将讨论主要系统性疾病中最常见的疾病，并探讨癫痫，性腺功能低下性腺功能减退症和系统性红斑狼疮之间的关系。病例报告一名23岁的男性在纳尔逊·曼德拉学术医院（Mthatha）出现，具有长期的癫痫控制史。他每天最多进行2次试身，全身性强直阵挛。该患者声称自己在外围诊所接受的未知剂量的卡马西平和苯巴比妥钠依从他的家人，根据他的家人，他的孩子发育正常，但在12岁时出现了黄斑疹，并抓住了所有发展进程。这种发育迟缓从未引起任何卫生工作者的注意。在检查中，患者身体状况良好，生命体征正常。明显有黄斑疹。他的身高异常矮小，为149厘米，没有继发性特征，只有右侧可触及的睾丸。全身检查，包括神经系统检查，均在正常范围内。

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