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Orbital Doppler Sonography and Documentation of Brain Death

机译:轨道多普勒超声检查和脑死亡文献记录

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Multiparametric confirmatory tests for documentation of brain death were studied from a 24-year-old subject with clinically defined brain death after severe head injury. The importance of transorbital ultrasound Doppler sonographic measurements is discussed. Introduction In recent years, fewer organs have been available for explantation eventhough new biomedical devices for confirmatory testing and determination of brain death have been developed [1,2,3,4,5,6,7]. Brain death or cerebral death is defined as irreversible cessation of all brain functions. However, it is difficult - indeed, impossible - to provide diagnostic standards for a condition that has never been adequately defined [8]. The documentation of brain death is primarily based on clinical criteria from neurologic examinations. In addition, tests including EEG recordings, evoked potentials, cerebral angiography, cerebral scintigraphy and more recently, transcranial Doppler ultrasonography (TCD), near infrared spectrsocopy (NIRS) and heart rate variability, are used to document the dynamics of cerebral ciruculatory arrest [9,10,11,12,13,14,15,16,17,18]. The aim of this present study was to examine transorbital and transtemporal Doppler sonographic recordings during the development of brain death in a 24-year-old patient. Materials and Methods SubjectA 24-year-old male subject from the intensive care unit with clinically defined brain death after severe head injury was investigated using combined multiparametric biosignal recordings. The study was approved by the ethics committee of the University of Graz (10-055 ex 99/00).Multidirectorial Transorbital and Transcranial Doppler Sonography Transorbital and transtemporal Doppler sonographic examinations were performed with a portable Multi-Dop T unit (DWL Electronic Systems GmbH, Sipplingen, Germany). A 4 MHz and a 2 MHz probe were used in a multidirectional ultrasound probe holder construction (Fig. 1). The monitoring arrangement for simultaneous recording of Doppler sonographic signals in the ophthalmic artery (OA) and the middle cerebral artery (MCA) was stationary at the circumference of the head. Blood flow profiles in the OA were measured transorbitally. Under acoustic control, the angle and position of the probes were adjusted until the greatest possible signal amplitude was reached.
机译:研究人员对一名24岁的严重颅脑损伤后脑死亡的受试者进行了多参数验证性测试,以记录脑死亡。讨论了经眶超声多普勒超声测量的重要性。引言近年来,尽管已经开发出用于确认试验和确定脑死亡的新型生物医学设备,但可供移植的器官却较少[1,2,3,4,5,6,7]。脑死亡或脑死亡定义为所有脑功能的不可逆转的停止。但是,为从未被充分定义的疾病提供诊断标准非常困难,甚至是不可能的[8]。脑死亡的记录主要基于神经系统检查的临床标准。此外,包括脑电图记录,诱发电位,脑血管造影,脑闪烁显像以及最近的经颅多普勒超声检查(TCD),近红外光谱(NIRS)和心率变异性在内的测试均用于记录脑循环停滞的动力学[9]。 ,10,11,12,13,14,15,16,17,18]。本研究的目的是检查一名24岁患者脑死亡发生过程中的经眶和颞颞多普勒超声记录。材料和方法受试者使用重症监护病房的24岁男性受试者,使用合并的多参数生物信号记录对严重颅脑损伤后脑死亡的临床定义进行了调查。该研究得到格拉茨大学伦理学委员会的批准(10-055 ex 99/00)。多方向经眶和经颅多普勒超声检查通过便携式多掺杂T装置(DWL Electronic Systems GmbH)进行经眶和经颞多普勒超声检查,德国西普林根)。在多向超声探头架结构中使用了4 MHz和2 MHz探头(图1)。用于同时记录眼动脉(OA)和大脑中动脉(MCA)中的多普勒超声信号的监视装置固定在头部周围。经眶测量OA中的血流曲线。在声学控制下,调整探头的角度和位置,直到达到最大可能的信号幅度。

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