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首页> 外文期刊>The International Journal of Alcohol and Drug Research >“Doc, I didn’t know I was pregnant. Does my baby have fetal alcohol spectrum disorder?”
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“Doc, I didn’t know I was pregnant. Does my baby have fetal alcohol spectrum disorder?”

机译：“医生，我不知道我怀孕了。我的宝宝有胎儿酒精谱障碍吗？”

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Green, C., & Cook, J. (2014). “Doc, I didn’t know I was pregnant. Does my baby have fetal alcohol spectrum disorder?”. The International Journal Of Alcohol And Drug Research, 3 (1), 117-120. doi:10.7895/ijadr.v3i1.176 How much alcohol is “safe” during pregnancy? This is a question for which there is no conclusive answer. Although no mother wants to intentionally harm her baby, the reality is that consuming alcohol during pregnancy can lead to a variety of complex developmental disabilities, collectively termed Fetal Alcohol Spectrum Disorder (FASD). The precise dosimetry data for the timing and dose of alcohol in pregnancy is unknown, but several features of alcohol metabolism are well characterized and have significant implications for alcohol’s deleterious effects on the developing fetus. There are a number of critical periods in embryonic development, which can be brief or prolonged and that correspond to specific tissues and structures (organ systems). Alcohol at any one of these critical periods can have significant downstream effects on typical fetal development. Alcohol teratogenicity does not produce a single abnormality, but instead can lead to a cluster of birth defects and/or neurodevelopmental abnormalities (i.e., FASD). Each of these cognitive or behavioral problems can vary in its expression, from severe and obvious early in life, to subtle and apparent only years after birth. Based on the variability among women and their fetuses, genetics and environmental influences, it is very unlikely that “absolute risk” for alcohol and pregnancy will ever be established. The age-old question, “How much is too much?”, will also remain unanswered. The best advice: “NO exposure equals NO risk.”
机译：Green，C.和Cook，J.（2014）。 “医生，我不知道我怀孕了。我的宝宝有胎儿酒精谱障碍吗？”。国际酒精与药物研究杂志，3（1），117-120。 doi：10.7895 / ijadr.v3i1.176怀孕期间多少酒精是“安全”的？这是一个尚无定论的问题。尽管没有母亲愿意故意伤害婴儿，但现实情况是，怀孕期间饮酒会导致多种复杂的发育障碍，统称为胎儿酒精频谱障碍（FASD）。怀孕期间饮酒的时间和剂量的精确剂量学数据尚不清楚，但是酒精代谢的几个特征已被很好地表征，并且对酒精对发育中的胎儿的有害影响具有重要意义。胚胎发育中有许多关键时期，这些时期可以短暂或延长，并与特定的组织和结构（器官系统）相对应。在这些关键时期的任何一个时期，酒精都会对典型的胎儿发育产生重大的下游影响。酒精致畸性不会产生单一异常，而是会导致一系列先天缺陷和/或神经发育异常（即FASD）。这些认知或行为问题中的每一个在表达上都可能有所不同，从生命的严重和明显开始到出生后仅几年的微妙和明显。根据妇女及其胎儿的变异性，遗传学和环境影响，极不可能确定酗酒和怀孕的“绝对风险”。古老的问题“多少钱太多了？”也将一直没有答案。最好的建议：“没有暴露等于没有风险。”

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