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外文期刊>The International Journal of Alcohol and Drug Research
>Retrospective assessment of prenatal alcohol exposure by detection of phosphatidylethanol in stored dried blood spot cards: An objective method for determining prevalence rates of alcohol consumption during pregnancy
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Retrospective assessment of prenatal alcohol exposure by detection of phosphatidylethanol in stored dried blood spot cards: An objective method for determining prevalence rates of alcohol consumption during pregnancy
Baldwin, A., Jones, J., Jones, M., Plate, C., & Lewis, D. (2015). Retrospective assessment of prenatal alcohol exposure by detection of phosphatidylethanol in stored dried blood spot cards: An objective method for determining prevalence rates of alcohol consumption during pregnancy. The International Journal Of Alcohol And Drug Research, 4 (2), 131-137. doi: http://dx.doi.org/10.7895/ijadr.v4i2.209 Aims: To analyze the efficacy of screening banked newborn dried blood spots (DBS) for detection of phosphatidylethanol (PEth), a direct alcohol biomarker, with the purpose of performing a retrospective assessment of statewide prevalence rates of alcohol consumption in late pregnancy that results in risky prenatal alcohol exposure. Design: Residual DBS samples collected for newborn screening and stored by a state department of public health were examined for concentrations of PEth. The prevalence of prenatal alcohol exposure, as determined by this direct alcohol biomarker, was compared to prevalence rates of alcohol consumption during pregnancy that have been derived from multiple state-based and national studies using maternal self-report surveys. Setting: DBS cards representative of the general newborn population were collected from multiple hospitals across a single midwestern state. Participants: Two hundred fifty anonymous newborn DBS collected for routine metabolic screening in a midwestern state were requested through the Virtual Repository of Dried Blood Spots. Measures: Concentrations of PEth, a highly specific biomarker of alcohol consumption, were analyzed using a liquid chromatography–tandem mass spectrometry method validated by our laboratory. Findings: Of 2 50 D BS e xamined, 4 % w ere p ositive f or PEth ( PEth ≥ 8 n g/ml) which is indicative of exposure to maternal alcohol consumption during the last month of pregnancy. Conclusions: Detection of PEth from newborn DBS cards can identify prenatal alcohol exposure and also be used for retrospective surveillance of alcohol consumption during the last three to four weeks of pregnancy, using specimens that are collected for routine metabolic screening and stored by many state health departments.
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机译：鲍德温（Baldwin，A.），琼斯（Jones），琼斯（J.），琼斯（M.通过检测储存的干血点卡中的磷脂酰乙醇对产前酒精暴露进行回顾性评估：一种确定怀孕期间饮酒流行率的客观方法。国际酒精与药物研究杂志，4（2），131-137。 doi：http://dx.doi.org/10.7895/ijadr.v4i2.209目的：分析筛查库存的新生儿干血斑（DBS）对磷脂酰乙醇（PEth）（一种直接的酒精生物标志物）的检测的有效性，目的是对妊娠后期全州范围内的饮酒流行率进行回顾性评估，以评估产前饮酒的风险。设计：收集用于新生儿筛查并由州公共卫生部门存储的DBS残留样品的PEth浓度。通过直接酒精生物标志物测定的产前酒精暴露发生率，与通过使用孕产妇自我报告调查从多个基于州和国家的研究得出的怀孕期间酒精消耗发生率进行了比较。设置：代表普通新生儿人口的DBS卡是从中西部一个州的多家医院收集的。参与者：通过干血斑虚拟储存库，要求收集中西部用于常规代谢筛查的250名匿名新生儿DBS。措施：PEth的浓度是酒精消耗的高度特异性生物标志物，已通过我们实验室验证的液相色谱-串联质谱法进行了分析。调查结果：在2次50 D BS胺中，有4％的F或PEth（PEth≥8 n g / ml）表示孕期最后一个月孕妇饮酒。结论：从新生儿DBS卡中检测到PEth可以识别产前酒精暴露，也可以用于妊娠最后三到四周的饮酒回顾性监测，使用的样本用于常规代谢筛查并由许多州卫生部门存储。
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