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首页> 外文期刊>The Internet Journal of Orthopedic Surgery >Ferritin: A multidimensional bio marker
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Ferritin: A multidimensional bio marker

机译：铁蛋白：多维生物标记

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Ferritin is a protein that playa a very important role in the storage of iron in the body. Ferritin is now emerging as a very important factor in the pathogenesis of diseases such as atherosclerosis , cancer , neuropsychiatric disorders to name a few. A number of mechanisms such as pro oxidant and pro inflammatory pathways are responsible for this. Ferritin performs diverse functions in the body besides iron storage. Alterations in the structure and concentration of ferritin have been observed in various diseases, establishing it as an important marker. The present review aims to understand the mechanisms involved in the cyto toxicity of iron and discuss some important disorders in which ferritin has emerged as an important bio marker. As ferritin has been established as a etiological factor in several disorders: pharmacological interventions to reduce its levels may prove beneficial . Indeed iron chelation therapy has been tried in various cancers with promising results.
机译：铁蛋白是一种蛋白质，在体内铁的存储中起着非常重要的作用。铁蛋白正在成为动脉粥样硬化，癌症，神经精神疾病等疾病发病机理中非常重要的因素。许多机制例如促氧化剂和促炎途径对此负责。铁蛋白除了可以储存铁以外，还可以在体内发挥多种功能。在各种疾病中均已观察到铁蛋白的结构和浓度发生变化，使其成为重要的标志物。本综述旨在了解铁的细胞毒性所涉及的机制，并讨论其中铁蛋白已作为重要的生物标志物出现的一些重要疾病。由于铁蛋白已被确定为多种疾病的病因，因此，降低其水平的药理干预可能被证明是有益的。实际上，铁螯合疗法已经在各种癌症中进行了尝试，并取得了可喜的结果。

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