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首页> 外文期刊>The Internet Journal of Orthopedic Surgery >Abo Blood Group And Total Serum Cholesterol Among Healthy Individuals In A Nigerian Population
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Abo Blood Group And Total Serum Cholesterol Among Healthy Individuals In A Nigerian Population

机译：尼日利亚人口健康个体的Abo血型和总血清胆固醇

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Background: High serum cholesterol is strongly implicated in the development of cardio vascular diseases. The relationships between ABO blood groups and cholesterol levels have been established but differ in many studies.Method: Two hundred and ten (210) students were recruited for this study (age ranging between 18-35 year). Blood groups and total serum cholesterol were determined.Result: A chi square test among the ABO blood groups and cholesterol levels is statistically significant at p < 0.05.Conclusion: This study shows that blood group A individuals have significant elevated serum cholesterol level compared to the remaining blood groups. Introduction Cholesterol is a steroid alcohol with a twenty seven carbon atom that is arranged in a tetra cyclic sterane skeleton found in the cell membranes and transported in the blood plasma of all animals. It is an essential component of mammalian cell membrane where it is required to establish proper membrane permeability and fluidity; it is use for the synthesis of bile acids which are essential for fat absorption, synthesis of many hormones among which are testosterone, estrogen, progesterone, cortisol etc. it also serve as protective antioxidant1. However, the main stream medical establishment has maintained that elevated serum cholesterol levels are a primary investigator of atherosclerosis and cardiovascular disease2-3. Millions of people worldwide have been convinced by extensive promotional campaigns’ that the key to avoiding cardiovascular disease is to reduce cholesterol level by using lipid lowering drugs and diets low in saturated fats 4. Cholesterol contrary to its popular image as a potent enemy of health and longetivity is actually a crucial substance that performs innumerable vital functions in the body 5.Several reports have appeared in recent years suggesting an association between blood groups and various manifestations of heart diseases6. During the last few decades, few reports have suggested that ABO blood groups are associated with the risk of ischemic heart diseases and of developing severe manifestation of atherosclerosis 7. While the war on cholesterol has proved to be extremely lucrative for food and drug industries, it has delivered no benefit to public health. Cardiovascular disease is still the leading cause of death in western countries. While the number of death from cardiovascular disease has indeed decreased since the late 1960’s, total incidence of cardiovascular disease has not declined8.Also scientists are interested in the study of the possible relationship between blood groups and ischemic heart disease9-10, and the relationship of blood groups to serum cholesterol11-12.A number of studies revealed that healthy men and women of blood group A have higher mean serum cholesterol levels than those of group O or B13-15. These studies implicated blood group A as risk factor for cardiac disease. The objective of this research is to find out whether there is a relationship between ABO blood group and total serum cholesterol among apparently healthy individuals. Materials and Method Two hundred and forty (240) students participated in the study. Two hundred and ten (210) comprising one hundred and fifty males and sixty females qualified for this work. Informed consent was sought individually before being enlisted for the study. A well structured questionnaire was given to each participant. Subjects used were undergraduate students of the University of Maiduguri aged between 18 and 35years. Demographic information of the subjects was age, height, sex, weight, blood pressure. The body mass index of each student was calculated using the formula (w/h2). Students with known cases of smoking obesity, diabetes, hypertension and other related disorders or those on medication were excluded from the study. Serum total cholesterol was determined by enzymatic colorimetric method as described by Trinder 16. The reagent kit was manufactured by Randox laboratories, Ant
机译：背景：高血清胆固醇与心血管疾病的发展密切相关。 ABO血型与胆固醇水平之间的关系已经建立，但在许多研究中存在差异。方法：招募了一百二十（210）名学生参加本研究（年龄在18-35岁之间）。结果：ABO血型和胆固醇水平之间的卡方检验在p <0.05上具有统计学意义。结论：这项研究表明，与ABO血型相比，A血型个体的血清胆固醇水平明显升高。剩余的血型。简介胆固醇是一种具有27个碳原子的甾族醇，排列在细胞膜的四环甾烷骨架中，并在所有动物的血浆中运输。它是哺乳动物细胞膜的重要组成部分，需要建立适当的膜渗透性和流动性。它用于合成对脂肪吸收必不可少的胆汁酸，合成许多激素，其中包括睾丸激素，雌激素，孕激素，皮质醇等。它还可以用作保护性抗氧化剂1。但是，主流医疗机构一直认为血清胆固醇水平升高是动脉粥样硬化和心血管疾病的主要研究者2-3。广泛的宣传活动已使全球数百万人确信，避免心血管疾病的关键是通过使用降脂药和低饱和脂肪饮食来降低胆固醇水平。4胆固醇与胆固醇作为健康和健康的强大敌人的普遍形象背道而驰。长寿实际上是在体内执行无数重要生命功能的关键物质。5近年来有几篇报道表明血型与心脏病的多种表现之间存在联系6。在过去的几十年中，很少有报告表明ABO血型与缺血性心脏病的风险和动脉粥样硬化的严重表现有关。7尽管胆固醇战已证明对食品和药品行业极为有利，对公共卫生没有任何好处。在西方国家，心血管疾病仍然是主要的死亡原因。尽管自1960年代后期以来因心血管疾病死亡的人数的确减少了，但心血管疾病的总发病率并未下降8。科学家还对研究血型与缺血性心脏病之间可能的关系以及9-10之间的关系感兴趣。血型与血清胆固醇的关系11-12。许多研究表明，血型A的健康男性和女性的平均血清胆固醇水平高于O或B13-15组。这些研究暗示A型血是心脏病的危险因素。这项研究的目的是找出在看起来健康的个体中ABO血型与总血清胆固醇之间是否存在关系。材料和方法240名（240）学生参加了这项研究。一百一百二十（210）名一百五十位男性和六十位女性合格。在征募参加研究之前，先寻求知情同意。为每个参与者提供了结构良好的问卷。使用的对象是Maiduguri大学的18至35岁的本科生。受试者的人口统计学信息是年龄，身高，性别，体重，血压。使用公式（w / h2）计算每个学生的体重指数。患有吸烟肥胖，糖尿病，高血压和其他相关疾病或正在服药的已知病例的学生被排除在研究之外。血清总胆固醇的测定采用Trinder 16中所述的酶比色法。试剂盒由Randox实验室Ant生产。

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