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首页> 外文期刊>The Internet journal of parasitic diseases >Epidemiological And Biochemical Studies Of Human Lymphatic Filariasis And Associated Parasitoses In Oguta, Southeastern Nigeria
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Epidemiological And Biochemical Studies Of Human Lymphatic Filariasis And Associated Parasitoses In Oguta, Southeastern Nigeria

机译：尼日利亚东南部奥古塔市人类淋巴丝虫病和相关寄生虫的流行病学和生化研究

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Possible organ infections associated with human filariasis, helminthiasis and malaria in Oguta Local Government Area of Imo State, Southeastern Nigeria were investigated. Blood, urine and stool samples were collected in appropriate containers from 200 male and female respondents aged 31 – 85 years. Parasitological studies were carried out on blood samples for malaria and/or microfilariae parasites while stool samples were tested for the presence of some intestinal parasites. The study showed a prevalence of intestinal protozoa (Entamoeba histolytica), Wuchereria bancrofti and the intestinal helminthes Ascaris lumbricoides and Hookworms. Biochemical parameters of liver integrity were also studied across the various infection cohorts among the respondents. Results obtained show that these parasitic infections depressed the haematological parameters relative to ‘normal’ respondents. Comparative biochemical analyses showed significant (p<.05) differences in some liver function parameters obtained for infected respondents relative to those not infected. There was also a positive correlation between age brackets with highest filarial infection (with no malarial coinfection) and age groups with elevated markers of liver dysfunction. This study can be of immense diagnostic value in the clinical management of the filariases especially in malaria-endemic and resource-poor areas. Introduction Till date the dream of eliminating some parasitic diseases like malaria and filariasis has not been fully realised. Instead, there appears to be a recrudescence of these old endemic debilitating parasitic diseases in some parts of developing countries. Malaria is still known to be the major cause of mortality and morbidity in the tropical and subtropical regions of the world (WHO, 2004) and is caused by Plasmodium species that have mosquitoes as their intermediate hosts and also serve as vectors of infective parasite stages to man. An added danger to malarial infections is that its effects and even recrudescence after intervention are usually worse with children (Borrmann et al, 2008).Filariasis on its own is a major public health problem in many parts of Asia, Africa, the Western Pacific and the Americas (Anosike et al, 2005). It is actually a group of diseases whose causative parasites have different vectors. Filariases are a group of vector – borne parasitic diseases of humans and other animals, caused by long, threadlike worms (hence the name “filaria” from Latin) that in their mature adult stages reside in the lymphatics or in connective tissue. Of the eight filarial parasites that commonly infect man three species account for most of the pathology associated with these infections: the lymphatic dwelling filariae Wuchereria bancrofti and Brugia malayi and the skin dwelling Onchocerca volvolus (Ottesen, 1984). Infection by Wuchereria bancrofti is the most common (Anosike et al, 2001) and accounts globally for approximately 90% of all infections. Worldwide, over 120 million people are infected with lymphatic filariasis and in Africa, the prevalence is especially striking, affecting over 40 million people in the sub-Saharan region alone. Overall, Africa is thought to account for 40% of all global cases (Lenhart et al 2007). The health, social and economic burdens of endemic tropical parasitic diseases have been assessed to include direct disease-related costs to individuals and households, costs to government-funded healthcare systems, lost productivity of infected individuals, and reduced productivity from structural changes in the economies of endemic villages (Evans et al, 1993; Gyapong et al, 1996; Haddix and Kestler, 2000). In Nigeria and elsewhere where diseases like helminthic infections, malaria and filariasis are endemic, the conventional diagnostic techniques are invasive and often times repetitive as different blood samples will be required for parasitological examination of filarial and malaria patients and confirmation is based on pos
机译：在尼日利亚东南部伊莫州的奥古塔地方政府地区，调查了可能与人类丝虫病，蠕虫病和疟疾有关的器官感染。从适当的容器中收集血液，尿液和粪便样本，这些容器来自200名年龄在31-85岁之间的男性和女性。对血液样本中的疟疾和/或微丝fil虫寄生虫进行了寄生虫学研究，同时对粪便样本中的某些肠道寄生虫进行了测试。研究表明，肠原生动物（Entomoeba histolytica），班氏无荚氏杆菌（Wuchereria bancrofti）和蠕虫类A虫（Ascaris lumbricoides）和钩虫（Hookworms）的流行。还在受访者的各种感染队列中研究了肝脏完整性的生化参数。获得的结果表明，相对于“正常”受访者，这些寄生虫感染会降低血液学参数。比较生化分析显示，与未感染者相比，被感染者获得的某些肝功能参数存在显着差异（p <.05）。丝虫感染最高的年龄段（无疟疾合并感染）与肝功能异常标志物升高的年龄段之间也呈正相关。这项研究对丝虫病的临床管理具有重要的诊断价值，尤其是在疟疾流行和资源贫乏地区。引言迄今为止，消除疟疾和丝虫病等寄生虫病的梦想尚未完全实现。取而代之的是，在发展中国家的某些地区，这些古老的流行性衰弱性寄生虫病似乎正在复发。疟疾仍被认为是世界热带和亚热带地区死亡率和发病率的主要原因（世界卫生组织，2004年），是由疟原虫物种引起的，疟原虫以蚊子为中间宿主，也可作为疟原虫感染性寄生虫的媒介。人。疟疾感染的另一个危险是，对儿童而言，其影响甚至是干预后的复发通常会更加严重（Borrmann等，2008）。在亚洲，非洲，西太平洋和非洲许多地区，丝虫病本身就是一个主要的公共卫生问题。美洲（Anosike等，2005）。它实际上是一组致病性寄生虫具有不同媒介的疾病。丝虫病是一组由人类和其他动物传播的由媒介引起的寄生虫病，是由长成线状的线虫（因此在拉丁语中称为“丝虫病”）引起的，这些线虫在成年阶段生活在淋巴管或结缔组织中。在通常感染人类的​​八种丝虫中，三种感染占大多数与这些感染有关的病理学：丝状丝虫Wuchereria bancrofti和马来布鲁氏菌以及皮肤上的厚皮Onchocerca volvolus（Ottesen，1984）。班克氏假单胞菌感染是最常见的（Anosike等，2001），全球约占所有感染的90％。在世界范围内，有超过1.2亿人感染了淋巴丝虫病，在非洲，这种流行尤为明显，仅在撒哈拉以南地区就影响了4000万人。总体而言，非洲被认为占全球所有病例的40％（Lenhart等，2007）。据评估，地方性热带寄生虫病的健康，社会和经济负担包括对个人和家庭的直接疾病相关费用，由政府资助的医疗系统的费用，受感染个体的生产力损失以及经济结构变化带来的生产力下降（Evans等，1993; Gyapong等，1996; Haddix和Kestler，2000）。在尼日利亚和其他地方，例如蠕虫感染，疟疾和丝虫病是地方病，传统的诊断技术具有侵入性，并且通常是重复性的，因为需要对丝虫和疟疾患者进行寄生虫学检查时需要使用不同的血样，并且基于

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